M, which correlates with an increase in mitochondrial DNA and also the expression of multiple mitochondrial genes [595,596]. To stop a mitochondrial biogenesis-associated improve in ROS levels, PGC-1 also induces expression of the antioxidant genes GPx1 and MnSOD [597]. 1 CXCL15 Proteins site permeability transition, as documented by membrane depolarization and calcium-induced swelling, which inhibits the oxidative.