Sis. K-HL, CAH and K-LT performed the functional ontology evaluation on
Sis. K-HL, CAH and K-LT performed the functional ontology analysis around the differentially expressed gene lists. P-SC, MAP, GKS, TT and HSS supervised and design the experiment. All von Hippel-Lindau (VHL) Species authors read and authorized the final manuscript. Acknowledgements This perform was supported by National Health and Health-related Analysis Council fellowships (461204 and APP1023059 to HSS); National Health and Medical Investigation Council Grants 219176, 257501, and 215201 (to HSS and GKS); Sciencefund Grant, MOSTI, Malaysia (02-01-04-SF1306) awarded to P-SC; plus the APEX Foundation for Analysis into Intellectual Disability Limited to CAH: K-HL was a PKCĪ± drug recipient of your Melbourne International Fee Remission Scholarship and Universiti Putra Malaysia Employees Education Scholarship, as well as a Adelaide Costs Scholarship International equivalent. K-LT and H-CL had been a recipient of Malaysian Ministry of Greater Education MyPhD scholarship. The microarrays were performed by the Australian Genome Investigation Facility, which was established by way of the Commonwealth-funded Big National Research Facilities program. The authors would like to thank Teresa Occhiodoro for editing assistance. Author particulars 1 Genetics and Regenerative Medicine Study Centre, Faculty of Medicine and Well being Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. 2Walter and Eliza Hall Institute of Healthcare Analysis, 1G Royal Parade, Parkville, Victoria 3052, Australia. 3Department of Obstetrics and Gynaecology, Faculty of Medicine and Overall health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. 4Pathology Department, The Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia. 5 Division of Human Anatomy, Faculty of Medicine and Overall health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. six Department of Pathology, Faculty of Medicine and Wellness Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. 7 Division of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia. 8Department of Molecular Pathology, SA Pathology and Centre for Cancer Biology, P.O. Box 14 Rundle Mall Post Office, Adelaide, South Australia 5000, Australia. 9School of Medicine, Faculty of Wellness Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia. Received: 23 May possibly 2014 Accepted: 16 July 2014 Published: 22 July 2014 References 1. Antonarakis SE, Lyle R, Dermitzakis ET, Reymond A, Deutsch S: Chromosome 21 and down syndrome: from genomics to pathophysiology. Nat Rev Genet 2004, 5:72538.eight.9.10.11.12.13.14.15.16.17.18.19.20.21.Van Cleve SN, Cannon S, Cohen WI: Part II: Clinical practice guidelines for adolescents and young adults with down syndrome: 12 to 21 Years. J Pediatr Health Care 2006, 20:19805. Van Cleve SN, Cohen WI: Aspect I: clinical practice suggestions for young children with Down syndrome from birth to 12 years. J Pediatr Well being Care 2006, 20:474. Vicari S, Bellucci S, Carlesimo GA: Visual and spatial long-term memory: differential pattern of impairments in Williams and Down syndromes. Dev Med Youngster Neurol 2005, 47:30511. Brown JH, Johnson MH, Paterson SJ, Gilmore R, Longhi E, Karmiloff-Smith A: Spatial representation and focus in toddlers with Williams syndrome and Down syndrome. Neuropsychologia 2003, 41:1037046. Kaufmann WE, Moser HW: Dendritic anomalies in disorders associated with mental retardation. Cereb Cortex 2000, 10:98191. Wisniewski KE: Down syndrome young children usually have brain with.