079085. 258. Calissano, P.; Matrone, C.; Amadoro, G. Nerve growth element as a

079085. 258. Calissano, P.; Matrone, C.; Amadoro, G. Nerve growth issue as a paradigm of neurotrophins related to Alzheimer’s illness. Dev. Neurobiol. 2010, 70, 37283. 259. Thies, E.; Mandelkow, E.M. Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J. Neurosci. 2007 27, 2896907. 260. Tatebayashi, Y.; Haque, N.; Tung, Y.C.; Iqbal, K.; Grundke-Iqbal, I. Part of tau phosphorylation by glycogen synthase kinase-3beta inside the regulation of organelle transport. J. Cell Sci. 2004, 117, 1653663. 261. Watson, F.L.; Heerssen, H.M.; Moheban, D.B.; Lin, M.Z.; Sauvageot, C.M.; Bhattacharyya, A.; Pomeroy, S.L.; Segal, R.A. Speedy nuclear responses to target-derived neurotrophins call for retrograde transport of ligand-receptor complicated. J. Neurosci. 1999, 15, 7889900. 262. Sandow, S.L.; Heydon, K.; Weible, M.W., II; Reynolds, A.J.; Bartlett, S.E.; Hendry, I.A. Signaling organelle for retrograde axonal transport of internalized neurotrophins in the nerve terminal. Immunol. Cell Biol. 2000, 78, 43035.Int. J. Mol. Sci. 2014,263. Bhattacharyya, A.; Watson, F.L.; Pomeroy, S.L.; Zhang, Y.Z.; Stiles, C.D.; Segal, R.A. High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors. J. Neurobiol. 2002, 51, 30212. 264. Heerssen, H.M.; Pazyra, M.F.; Segal, R.A. Dynein motors transport activated Trks to promote survival of target-dependent neurons. Nat. Neurosci. 2004, 7, 59604. 265. Yano, H.; Lee, F.S.; Kong, H.; Chuang, J.; Arevalo, J.; Perez, P.; Sung, C.; Chao, M.V. Association of Trk neurotrophin receptors with components on the cytoplasmic dynein motor. J. Neurosci. 2001, 21, RC125. 266. Yano, H.; Chao, M.V. Mechanisms of neurotrophin receptor vesicular transport. J. Neurobiol. 2004, 58, 24457. 267. Riccio, A.; Pierchal, B.A.; Ciarallo, C.L.; Ginty, D.D. A NGF-TrkA-mediated retrograde signal to transcription issue CREB in sympathetic neurons. Science 1997, 277, 1097100. 268. Yano, H.; Chao, M.V. Biochemical characterization of intracellular membranes bearing Trk neurotrophin receptors. Neurochem. Res. 2005, 30, 76777. 269. Wu, C.; Ramirez, A.; Cui, B.; Ding, J.; Delcroix, J.D.; Valletta, J.S.; Liu, J.J.; Yang, Y.; Chu, S.; Mobley, W.C. A functional dynein-microtubule network is required for NGF signaling by way of the Rap1/MAPK pathway. Website traffic 2007, eight, 1503520. 270. Salehi, A.; Delcroix, J.D.; Swaab, D.F. Alzheimer’s illness and NGF signaling. J. Neural Transm. 2004, 111, 32345. 271. Schindowski, K.; Belarbi, K.; Bu , L. Neurotrophic components in Alzheimer’s disease: Function of axonal transport. Genes Brain Behav. 2008, 1, 436. 272. Lazarov, O.1-Deoxynojirimycin ; Morfini, G.Ixazomib A.PMID:32472497 ; Pigino, G.; Gadadhar, A.; Chen, X.; Robinson, J.; Ho, H.; Brady, S.T.; Sisodia, S.S. Impairments in quickly axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer’s disease-linked mutant presenilin 1. J. Neurosci. 2007, 27, 7011020. 273. Corsetti, V.; Amadoro, G.; Gentile, A.; Capsoni, S.; Ciotti, M.T.; Cencioni, M.T.; Atlante, A.; Canu, N.; Rohn, T.T.; Cattaneo, A.; et al. Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer’s disease models. Mol. Cell. Neurosci. 2008, 38, 38192. 274. Magnani, E.; Fan, J.; Gasparini, L.; Golding, M.; Williams, M.; Schiavo, G.; Goedert, M.; Amos, L.A.; Spillantini, M.G. Interaction of tau protein with all the dynactin complex. EMBO J. 2007, 31, 4546554. 275. Matrone, C.; Ciotti, M.T.; Mercanti, D.; Marolda, R.; Ca.