Product Name :
SB 204990
Description:
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.
CAS:
154566-12-8
Molecular Weight:
389.27
Formula:
C18H22Cl2O5
Chemical Name:
2-[(3S,5R)-5-[6-(2,4-dichlorophenyl)hexyl]-3-hydroxy-2-oxooxolan-3-yl]acetic acid
Smiles :
OC(=O)C[C@@]1(O)C[C@@H](CCCCCCC2=CC=C(Cl)C=C2Cl)OC1=O
InChiKey:
YTRNLFYTHYWDAU-KDOFPFPSSA-N
InChi :
InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.|Product information|CAS Number: 154566-12-8|Molecular Weight: 389.27|Formula: C18H22Cl2O5|Chemical Name: 2-[(3S,5R)-5-[6-(2,4-dichlorophenyl)hexyl]-3-hydroxy-2-oxooxolan-3-yl]acetic acid|Smiles: OC(=O)C[C@@]1(O)C[C@@H](CCCCCCC2=CC=C(Cl)C=C2Cl)OC1=O|InChiKey: YTRNLFYTHYWDAU-KDOFPFPSSA-N|InChi: InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (256.{{Laquinimod} MedChemExpress|{Laquinimod} NF-κB|{Laquinimod} Purity & Documentation|{Laquinimod} Formula|{Laquinimod} manufacturer|{Laquinimod} Epigenetics} 89 mM).{{Indole-3-carbinol} web|{Indole-3-carbinol} NF-κB|{Indole-3-carbinol} Technical Information|{Indole-3-carbinol} In Vitro|{Indole-3-carbinol} supplier|{Indole-3-carbinol} Autophagy} H2O : 10 mg/mL (25.PMID:23907521 69 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels.|In Vivo:|SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.|Products are for research use only. Not for human use.|