Product Name :
Abeprazan
Description:
Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.
CAS:
1902954-60-2
Molecular Weight:
410.41
Formula:
C19H17F3N2O3S
Chemical Name:
{[5-(2,4-difluorophenyl)-1-(3-fluorobenzenesulfonyl)-4-methoxy-1H-pyrrol-3-yl]methyl}(methyl)amine
Smiles :
CNCC1=CN(C(=C1OC)C1=CC=C(F)C=C1F)S(=O)(=O)C1=CC(F)=CC=C1
InChiKey:
OUNXGNDVWVPCOL-UHFFFAOYSA-N
InChi :
InChI=1S/C19H17F3N2O3S/c1-23-10-12-11-24(28(25,26)15-5-3-4-13(20)8-15)18(19(12)27-2)16-7-6-14(21)9-17(16)22/h3-9,11,23H,10H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.|Product information|CAS Number: 1902954-60-2|Molecular Weight: 410.41|Formula: C19H17F3N2O3S|Chemical Name: {[5-(2,4-difluorophenyl)-1-(3-fluorobenzenesulfonyl)-4-methoxy-1H-pyrrol-3-yl]methyl}(methyl)amine|Smiles: CNCC1=CN(C(=C1OC)C1=CC=C(F)C=C1F)S(=O)(=O)C1=CC(F)=CC=C1|InChiKey: OUNXGNDVWVPCOL-UHFFFAOYSA-N|InChi: InChI=1S/C19H17F3N2O3S/c1-23-10-12-11-24(28(25,26)15-5-3-4-13(20)8-15)18(19(12)27-2)16-7-6-14(21)9-17(16)22/h3-9,11,23H,10H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bethanechol} medchemexpress|{Bethanechol} Neuronal Signaling|{Bethanechol} Protocol|{Bethanechol} Formula|{Bethanechol} manufacturer|{Bethanechol} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{TCEP} web|{TCEP} Purity & Documentation|{TCEP} Purity|{TCEP} manufacturer|{TCEP} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23937941 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The mechanism of action of Abeprazan is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation.|In Vivo:|DWP14012 inhibited acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion was equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models.|Products are for research use only. Not for human use.|