Product Name :
Apoptozole
Description:
Apoptozole (Apoptosis Activator VII) is an inhibitor of heat shock protein 70(HSP70) and Hsc70 with dissociation constants Kd of 0.14 μM and 0.21 μM, respectively. It induces caspase-dependent apoptosis.
CAS:
1054543-47-3
Molecular Weight:
625.56
Formula:
C33H25F6N3O3
Chemical Name:
4-({2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl}methyl)benzamide
Smiles :
COC1C=CC(=CC=1)C1N=C(C2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)N(CC2C=CC(=CC=2)C(N)=O)C=1C1C=CC(=CC=1)OC
InChiKey:
ZIMMTPFXOMAJTQ-UHFFFAOYSA-N
InChi :
InChI=1S/C33H25F6N3O3/c1-44-26-11-7-20(8-12-26)28-29(21-9-13-27(45-2)14-10-21)42(18-19-3-5-22(6-4-19)30(40)43)31(41-28)23-15-24(32(34,35)36)17-25(16-23)33(37,38)39/h3-17H,18H2,1-2H3,(H2,40,43)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Apoptozole (Apoptosis Activator VII) is an inhibitor of heat shock protein 70(HSP70) and Hsc70 with dissociation constants Kd of 0.14 μM and 0.21 μM, respectively. It induces caspase-dependent apoptosis.|Product information|CAS Number: 1054543-47-3|Molecular Weight: 625.56|Formula: C33H25F6N3O3|Chemical Name: 4-({2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl}methyl)benzamide|Smiles: COC1C=CC(=CC=1)C1N=C(C2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)N(CC2C=CC(=CC=2)C(N)=O)C=1C1C=CC(=CC=1)OC|InChiKey: ZIMMTPFXOMAJTQ-UHFFFAOYSA-N|InChi: InChI=1S/C33H25F6N3O3/c1-44-26-11-7-20(8-12-26)28-29(21-9-13-27(45-2)14-10-21)42(18-19-3-5-22(6-4-19)30(40)43)31(41-28)23-15-24(32(34,35)36)17-25(16-23)33(37,38)39/h3-17H,18H2,1-2H3,(H2,40,43)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C). 100 mg/mL(159.85 mM). Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Apoptozole induces caspase dependent apoptosis by blocking interaction of HSP70 with APAF-1, without affecting interactions of HSP70 with ASK1, JNK, BAX, and AIF.{{Ustekinumab} web|{Ustekinumab} Immunology/Inflammation|{Ustekinumab} Protocol|{Ustekinumab} In Vivo|{Ustekinumab} supplier|{Ustekinumab} Autophagy} However, apoptozole may form aggregates under aqueous conditions that could interact with HSP70 proteins in a non-specific manner, potentially leading to false positives and inconsistent data.{{Ceftazidime} medchemexpress|{Ceftazidime} Beta-lactamase|{Ceftazidime} Purity & Documentation|{Ceftazidime} Data Sheet|{Ceftazidime} manufacturer|{Ceftazidime} Autophagy} |In Vivo:|Apoptozole greatly retards tumor growth in mice xenografted with cancer cells without affecting mouse viability.PMID:24458656 The elimination half-life time (T1/2) of Az in blood is found to be significantly longer than that of Dox (8.04 versus 1.60 hr) and the time needed to reach a maximum concentration (Tmax) of Az is shorter than that of Dox (1.00 versus 4.00 hr).|Products are for research use only. Not for human use.|