Product Name :
Org41841
Description:
Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.
CAS:
301847-37-0
Molecular Weight:
402.53
Formula:
C19H22N4O2S2
Chemical Name:
5-amino-N-tert-butyl-4-(3-methoxyphenyl)-2-(methylsulfanyl)thieno[2,3-d]pyrimidine-6-carboxamide
Smiles :
CSC1=NC(=C2C(N)=C(SC2=N1)C(=O)NC(C)(C)C)C1C=C(C=CC=1)OC
InChiKey:
DVSFSADBOJYPGF-UHFFFAOYSA-N
InChi :
InChI=1S/C19H22N4O2S2/c1-19(2,3)23-16(24)15-13(20)12-14(10-7-6-8-11(9-10)25-4)21-18(26-5)22-17(12)27-15/h6-9H,20H2,1-5H3,(H,23,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.|Product information|CAS Number: 301847-37-0|Molecular Weight: 402.53|Formula: C19H22N4O2S2|Chemical Name: 5-amino-N-tert-butyl-4-(3-methoxyphenyl)-2-(methylsulfanyl)thieno[2,3-d]pyrimidine-6-carboxamide|Smiles: CSC1=NC(=C2C(N)=C(SC2=N1)C(=O)NC(C)(C)C)C1C=C(C=CC=1)OC|InChiKey: DVSFSADBOJYPGF-UHFFFAOYSA-N|InChi: InChI=1S/C19H22N4O2S2/c1-19(2,3)23-16(24)15-13(20)12-14(10-7-6-8-11(9-10)25-4)21-18(26-5)22-17(12)27-15/h6-9H,20H2,1-5H3,(H,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (248.{{Masofaniten} web|{Masofaniten} Androgen Receptor|{Masofaniten} NF-κB|{Masofaniten} Technical Information|{Masofaniten} In stock|{Masofaniten} custom synthesis} 43 mM; Need ultrasonic).{{Epalrestat} medchemexpress|{Epalrestat} Metabolic Enzyme/Protease|{Epalrestat} Protocol|{Epalrestat} In stock|{Epalrestat} manufacturer|{Epalrestat} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23443926 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC50 of 800 nM. M9 responds to Org41841 with an improved EC50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR).|Products are for research use only. Not for human use.|