Product Name :
Celastramycin A
Description:
Celastramycin A is an antibiotic that inhibits the growth of bacteria and mycobacteria and is also a potent innate immune suppressor . Celastramycin A is a benzoyl pyrrole-type compound isolated from endophytic bacteria Streptomyces MaB-QuH-8 living in plants of the Celastraceae family. Celastramycin A exhibited high activity against a series of multiresistent bacteria and mycobacteria . Celastramycin A inhibited the growth of Gram-positive bacteria and mycobacteria with minimal inhibitory concentration (MIC) as low as 0.05 μg/ml . In the ex vivo Drosophila culture system, Celastramycin A showed a potent immunosuppressive effect with IC50 value of 0.008 μg/mL. In human umbilical vein endothelial cells (HUVECs), Celastramycin A potently inhibited the production of IL-8 with IC50 value of 0.06 μg/mL. So Celastramycin A could be used as a lead compound for novel immunosuppressive agents .
CAS:
491600-94-3
Molecular Weight:
390.69
Formula:
C17H18Cl3NO3
Chemical Name:
4-chloro-2-(4,5-dichloro-1H-pyrrole-2-carbonyl)-6-hexylbenzene-1,3-diol
Smiles :
CCCCCCC1C=C(Cl)C(O)=C(C(=O)C2=CC(Cl)=C(Cl)N2)C=1O
InChiKey:
VPAMZQVPJOAFJG-UHFFFAOYSA-N
InChi :
InChI=1S/C17H18Cl3NO3/c1-2-3-4-5-6-9-7-10(18)15(23)13(14(9)22)16(24)12-8-11(19)17(20)21-12/h7-8,21-23H,2-6H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{DREADD agonist 21} MedChemExpress|{DREADD agonist 21} Neuronal Signaling|{DREADD agonist 21} Epigenetics|{DREADD agonist 21} Protocol|{DREADD agonist 21} In Vitro|{DREADD agonist 21} supplier}
Shelf Life:
≥12 months if stored properly.{{Enrofloxacin} MedChemExpress|{Enrofloxacin} Antibiotic|{Enrofloxacin} Purity & Documentation|{Enrofloxacin} In Vitro|{Enrofloxacin} supplier|{Enrofloxacin} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:26644518
Additional information:
Celastramycin A is an antibiotic that inhibits the growth of bacteria and mycobacteria and is also a potent innate immune suppressor . Celastramycin A is a benzoyl pyrrole-type compound isolated from endophytic bacteria Streptomyces MaB-QuH-8 living in plants of the Celastraceae family. Celastramycin A exhibited high activity against a series of multiresistent bacteria and mycobacteria . Celastramycin A inhibited the growth of Gram-positive bacteria and mycobacteria with minimal inhibitory concentration (MIC) as low as 0.05 μg/ml . In the ex vivo Drosophila culture system, Celastramycin A showed a potent immunosuppressive effect with IC50 value of 0.008 μg/mL. In human umbilical vein endothelial cells (HUVECs), Celastramycin A potently inhibited the production of IL-8 with IC50 value of 0.06 μg/mL. So Celastramycin A could be used as a lead compound for novel immunosuppressive agents .|Product information|CAS Number: 491600-94-3|Molecular Weight: 390.69|Formula: C17H18Cl3NO3|Chemical Name: 4-chloro-2-(4,5-dichloro-1H-pyrrole-2-carbonyl)-6-hexylbenzene-1,3-diol|Smiles: CCCCCCC1C=C(Cl)C(O)=C(C(=O)C2=CC(Cl)=C(Cl)N2)C=1O|InChiKey: VPAMZQVPJOAFJG-UHFFFAOYSA-N|InChi: InChI=1S/C17H18Cl3NO3/c1-2-3-4-5-6-9-7-10(18)15(23)13(14(9)22)16(24)12-8-11(19)17(20)21-12/h7-8,21-23H,2-6H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|