Product Name :
Hematoporphyrin monomethyl ether
Description:
Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and treatment of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma.
CAS:
148471-91-4
Molecular Weight:
612.72
Formula:
C35H40N4O6
Chemical Name:
3-[20-(2-carboxyethyl)-14-(1-hydroxyethyl)-9-(1-methoxyethyl)-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1,3(24),4,6,8,10,12,14,16,18(21),19-undecaen-4-yl]propanoic acid
Smiles :
CC(O)C1C2=CC3NC(C=C4N=C(C=C5N=C(C=C(N2)C=1C)C(C)=C5CCC(O)=O)C(CCC(O)=O)=C4C)=C(C(C)OC)C=3C
InChiKey:
NDYWLKUTUDKOAS-OYYVZGGRSA-N
InChi :
InChI=1S/C35H40N4O6/c1-16-22(8-10-32(41)42)28-15-29-23(9-11-33(43)44)17(2)25(37-29)13-31-35(21(6)45-7)19(4)27(39-31)14-30-34(20(5)40)18(3)26(38-30)12-24(16)36-28/h12-15,20-21,38-40H,8-11H2,1-7H3,(H,41,42)(H,43,44)/b24-12-,25-13-,26-12-,27-14-,28-15-,29-15-,30-14-,31-13-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Lebrikizumab} MedChemExpress|{Lebrikizumab} Immunology/Inflammation|{Lebrikizumab} Purity & Documentation|{Lebrikizumab} Data Sheet|{Lebrikizumab} custom synthesis|{Lebrikizumab} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Fedratinib} MedChemExpress|{Fedratinib} JAK|{Fedratinib} Protocol|{Fedratinib} In Vitro|{Fedratinib} custom synthesis|{Fedratinib} Autophagy}
Additional information:
Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and treatment of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma.PMID:32967527 |Product information|CAS Number: 148471-91-4|Molecular Weight: 612.72|Formula: C35H40N4O6|Chemical Name: 3-[20-(2-carboxyethyl)-14-(1-hydroxyethyl)-9-(1-methoxyethyl)-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1,3(24),4,6,8,10,12,14,16,18(21),19-undecaen-4-yl]propanoic acid|Smiles: CC(O)C1C2=CC3NC(C=C4N=C(C=C5N=C(C=C(N2)C=1C)C(C)=C5CCC(O)=O)C(CCC(O)=O)=C4C)=C(C(C)OC)C=3C|InChiKey: NDYWLKUTUDKOAS-OYYVZGGRSA-N|InChi: InChI=1S/C35H40N4O6/c1-16-22(8-10-32(41)42)28-15-29-23(9-11-33(43)44)17(2)25(37-29)13-31-35(21(6)45-7)19(4)27(39-31)14-30-34(20(5)40)18(3)26(38-30)12-24(16)36-28/h12-15,20-21,38-40H,8-11H2,1-7H3,(H,41,42)(H,43,44)/b24-12-,25-13-,26-12-,27-14-,28-15-,29-15-,30-14-,31-13-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Hematoporphyrin monomethyl ether (HMME) is a novel and promising porphyrin-related photosensitizer for photodynamic therapy (PDT). HMME-PDT can induce cell deaththrough both necrosis and apoptosis in HeLa cells. ROS, such as singlet oxygen and hydroxyl radical, generated in HeLa cells play a decisive role in HMME-PDT-induced cell death.|Products are for research use only. Not for human use.|