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INSM1 monoclonal antibody (A-8)
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INSM1 (A-8) Mouse Monoclonal Antibody is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, to be viewed by light microscopy. INSM1 (Insulinoma-associated protein 1) is a transcription factor primarily known for its role in neuroendocrine differentiation and development. It is expressed in various neuroendocrine tissues and tumors, including pancreatic neuroendocrine tumors (NETs), neuroendocrine lung tumors, and neuroendocrine carcinomas of the gastrointestinal tract. INSM1 plays a crucial role in regulating the expression of genes involved in neuroendocrine cell fate determination, differentiation, and hormone production. Its expression pattern and potential diagnostic and prognostic significance make it a valuable biomarker in neuroendocrine tumor pathology and research. Formalin fixed paraffin embedded human pancreas stained with INSM1 antibody, 25x Formalin fixed paraffin embedded human pancreas stained with INSM1 antibody, 25x
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| Alternative Name Insulinoma-associated protein 1 | Application IHC (PS) | Application Notes Pretreatment: Tris/EDTA Buffer pH 8.{{130308-48-4} medchemexpress|{130308-48-4} Protocol|{130308-48-4} In Vivo|{130308-48-4} supplier} 0 | Clone A-8 | Formulation This product is supplied as an immunoglobulin and contains sodium azide as a preservative | Host Mouse | Immunogen Amino acid 81-125 at the N-terminus of human INSM1 | Isotype IgG1, kappa | Positive Control Neuroendocrine tumor | Recommendation Dilutions/Conditions 1:50 – 1:200Antibody dilutions should be appropriately adjusted and verified according to the detection system used.{{2883540-92-7} web|{2883540-92-7} Biological Activity|{2883540-92-7} In stock|{2883540-92-7} manufacturer} Optimal conditions must be determined individually for each application.PMID:31424829 | Species Reactivity Human | Unit of Measure (UM) ml, µl