Product Name :
p70 S6 kinase (human), (recombinant)
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71 kDa
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Description:
p70 S6K was first identified as the kinase responsible for the phosphorylation of the S6 ribosomal protein. Research has raised the possibility that S6K might, in fact, be the rapamycin-sensitive effector responsible for directly phosphorylating IRS-1 and thereby inhibiting PI 3-kinase activation. Another study suggests that S6K1 activation may mediate some of the effects of a high-fat diet on inhibiting the insulin-PI 3-kinase signaling pathway3. This makes S6K1 a promising new therapeutic target in the fight against type 2 diabetes.
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| Alternative Name p70 S6K | Application Notes Useful for Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening.{{916821-46-0} MedChemExpress|{916821-46-0} Protocol|{916821-46-0} In stock|{916821-46-0} manufacturer} | Formulation Liquid.{{301836-41-9} medchemexpress|{301836-41-9} Biological Activity|{301836-41-9} In Vivo|{301836-41-9} custom synthesis} In 50mM sodium phosphate, pH 7.PMID:30252324 0, containing 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, and 25% glycerol. | MW 71 kDa | Source Produced in insect cells. Active, full length p70 S6K. Produced in a baculovirus expression system. | Technical Info / Product Notes Replacement for ADI-PPK-439 | UniProt ID P23443 (S6K1), Q9UBS0 (S6K2)