Product Name :
DC260126
Description:
DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively). DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis.
CAS:
346692-04-4
Molecular Weight:
307.38
Formula:
C16H18FNO2S
Chemical Name:
N-(4-butylphenyl)-4-fluorobenzene-1-sulfonamide
Smiles :
CCCCC1C=CC(=CC=1)NS(=O)(=O)C1C=CC(F)=CC=1
InChiKey:
CNGHPXKWPGIDSK-UHFFFAOYSA-N
InChi :
InChI=1S/C16H18FNO2S/c1-2-3-4-13-5-9-15(10-6-13)18-21(19,20)16-11-7-14(17)8-12-16/h5-12,18H,2-4H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} site|{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} Immunology/Inflammation|{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} TGF-beta/Smad|{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} Biological Activity|{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} In Vivo|{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} supplier}
Additional information:
DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively). DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis.|Product information|CAS Number: 346692-04-4|Molecular Weight: 307.38|Formula: C16H18FNO2S|Chemical Name: N-(4-butylphenyl)-4-fluorobenzene-1-sulfonamide|Smiles: CCCCC1C=CC(=CC=1)NS(=O)(=O)C1C=CC(F)=CC=1|InChiKey: CNGHPXKWPGIDSK-UHFFFAOYSA-N|InChi: InChI=1S/C16H18FNO2S/c1-2-3-4-13-5-9-15(10-6-13)18-21(19,20)16-11-7-14(17)8-12-16/h5-12,18H,2-4H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (325.33 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Teropavimab} MedChemExpress|{Teropavimab} HIV|{Teropavimab} Activator|{Teropavimab} Technical Information|{Teropavimab} Description|{Teropavimab} custom synthesis} |Shelf Life: ≥360 days if stored properly.PMID:33207974 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DC260126 reduces GTP-loading and ERK1/2 phosphorylation stimulated by linoleic acid in GPR40-CHO cells, suppresses palmitic acid potentiated glucose-stimulated insulin secretion, and negatively regulates GPR40 mRNA expression induced by oleic acid in Min6 cells.|References:|Hu H, et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem Biophys Res Commun. 2009;390(3):557-563.Wu J, et al. Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis [published correction appears in J Cell Biochem. 2013 May;114(5):1216]. J Cell Biochem. 2012;113(4):1152-1158.Products are for research use only. Not for human use.|