DAD

Additional information:
DAD is a type of ion channel blocker that blocks voltage-gated potassium channels. DAD is a third-generation photoswitch that responds to visible light. DAD has the potential for restoring visual function.|Product information|Molecular Weight: 452.64|Formula: C26H40N6O|Chemical Name: (E)-2-(diethylamino)-N-(4-((4-((2-(diethylamino)ethyl)(ethyl)amino)phenyl)diazenyl)phenyl)acetamide|Smiles: CCN(CCN(CC)CC)C1C=CC(=CC=1)/N=N/C1C=CC(=CC=1)NC(=O)CN(CC)CC|InChiKey: WQECYMBPMDXORX-ZQHSETAFSA-N|InChi: InChI=1S/C26H40N6O/c1-6-30(7-2)19-20-32(10-5)25-17-15-24(16-18-25)29-28-23-13-11-22(12-14-23)27-26(33)21-31(8-3)9-4/h11-18H,6-10,19-21H2,1-5H3,(H,27,33)/b29-28+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Sabizabulin Cytoskeleton |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DAD is not permanently charged, and the uncharged form enables the photoswitch to rapidly and effectively cross biological barriers and thereby access and photosensitize retinal neurons.Polatuzumab site DAD selectively photosensitizes retinal neurons upstream of retinal ganglion cells (RGCs).PMID:33037407 DAD is capable of restoring retinal ganglion cell light responses to blue or white light.|In Vivo:|Intravitreal injection of DAD restores retinal light responses and light-driven behavior to blind mice. DAD acts upstream of retinal ganglion cells, primarily conferring light sensitivity to bipolar cells. DAD is capable of generating ON and OFF visual responses in the blind retina by utilizing intrinsic retinal circuitry.|Products are for research use only. Not for human use.|