Product Name :
MOMIPP
Description:
MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).
CAS:
1363421-46-8
Molecular Weight:
292.33
Formula:
C18H16N2O2
Chemical Name:
(2E)-3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one
Smiles :
CC1NC2=CC=C(C=C2C=1/C=C/C(=O)C1C=CN=CC=1)OC
InChiKey:
UPJCYXIOWHZRLU-GQCTYLIASA-N
InChi :
InChI=1S/C18H16N2O2/c1-12-15(4-6-18(21)13-7-9-19-10-8-13)16-11-14(22-2)3-5-17(16)20-12/h3-11,20H,1-2H3/b6-4+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Maslinic acid} medchemexpress|{Maslinic acid} HIV|{Maslinic acid} Protocol|{Maslinic acid} Data Sheet|{Maslinic acid} custom synthesis|{Maslinic acid} Autophagy}
Shelf Life:
≥12 months if stored properly.{{FMK-MEA} medchemexpress|{FMK-MEA} MAPK/ERK Pathway|{FMK-MEA} Protocol|{FMK-MEA} References|{FMK-MEA} supplier|{FMK-MEA} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23357584
Additional information:
MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).|Product information|CAS Number: 1363421-46-8|Molecular Weight: 292.33|Formula: C18H16N2O2|Chemical Name: (2E)-3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one|Smiles: CC1NC2=CC=C(C=C2C=1/C=C/C(=O)C1C=CN=CC=1)OC|InChiKey: UPJCYXIOWHZRLU-GQCTYLIASA-N|InChi: InChI=1S/C18H16N2O2/c1-12-15(4-6-18(21)13-7-9-19-10-8-13)16-11-14(22-2)3-5-17(16)20-12/h3-11,20H,1-2H3/b6-4+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations. In U373 and Hs683 cell lines, 3 µM for MOMIPP induces cell vacuolization. MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL.|In Vivo:|MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts.|References:|Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77.Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411.Products are for research use only. Not for human use.|