Product Name :
MFZ 10-7 hydrochloride
Description:
MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 hydrochloride inhibits cocaine-taking and cocaine-seeking behavior in rats.
CAS:
1779796-36-9
Molecular Weight:
272.70
Formula:
C15H10ClFN2
Chemical Name:
3-fluoro-5-[2-(6-methylpyridin-2-yl)ethynyl]benzonitrile; chlorohydrogen
Smiles :
Cl.CC1=CC=CC(C#CC2C=C(C=C(F)C=2)C#N)=N1
InChiKey:
WRHOKQFFLQKKNL-UHFFFAOYSA-N
InChi :
InChI=1S/C15H9FN2.ClH/c1-11-3-2-4-15(18-11)6-5-12-7-13(10-17)9-14(16)8-12;/h2-4,7-9H,1H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 hydrochloride inhibits cocaine-taking and cocaine-seeking behavior in rats.|Product information|CAS Number: 1779796-36-9|Molecular Weight: 272.70|Formula: C15H10ClFN2|Chemical Name: 3-fluoro-5-[2-(6-methylpyridin-2-yl)ethynyl]benzonitrile; chlorohydrogen|Smiles: Cl.CC1=CC=CC(C#CC2C=C(C=C(F)C=2)C#N)=N1|InChiKey: WRHOKQFFLQKKNL-UHFFFAOYSA-N|InChi: InChI=1S/C15H9FN2.ClH/c1-11-3-2-4-15(18-11)6-5-12-7-13(10-17)9-14(16)8-12;/h2-4,7-9H,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fremanezumab} web|{Fremanezumab} CGRP Receptor|{Fremanezumab} Protocol|{Fremanezumab} Purity|{Fremanezumab} custom synthesis|{Fremanezumab} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Tolcapone} medchemexpress|{Tolcapone} COMT|{Tolcapone} Purity & Documentation|{Tolcapone} Description|{Tolcapone} manufacturer|{Tolcapone} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23891445 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MFZ 10-7 hydrochloride has approximately 1150- and 3000-fold lower affinity for MAO-B (monoamine oxidase-B enzyme) and TXA2 (thromboxane A2 receptor), respectively, compared to mGluR5.|In Vivo:|MFZ 10-7 hydrochloride (3 mg/kg, 10 mg/kg; i.p.) inhibits cocaine self-administration in rats. MFZ 10-7 hydrochloride can lower oral sucrose self-administration rate but has no effect on total sucrose intake.|Products are for research use only. Not for human use.|