Product Name :
HSR6071
Description:
HSR6071, a pyrazinecarboxamide derivative, is an orally active and potent antiallergic agent. HSR6071 potently inhibits the experimental asthma in rat models.
CAS:
111374-21-1
Molecular Weight:
260.26
Formula:
C10H12N8O
Chemical Name:
6-(pyrrolidin-1-yl)-N-(2H-1,2,3,4-tetrazol-5-yl)pyrazine-2-carboxamide
Smiles :
O=C(NC1N=NNN=1)C1=CN=CC(=N1)N1CCCC1
InChiKey:
LUJDHCXCWJFNOJ-UHFFFAOYSA-N
InChi :
InChI=1S/C10H12N8O/c19-9(13-10-14-16-17-15-10)7-5-11-6-8(12-7)18-3-1-2-4-18/h5-6H,1-4H2,(H2,13,14,15,16,17,19)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Purmorphamine} web|{Purmorphamine} Activator|{Purmorphamine} Epigenetics|{Purmorphamine} Biological Activity|{Purmorphamine} In Vivo|{Purmorphamine} supplier}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
HSR6071, a pyrazinecarboxamide derivative, is an orally active and potent antiallergic agent. HSR6071 potently inhibits the experimental asthma in rat models.|Product information|CAS Number: 111374-21-1|Molecular Weight: 260.26|Formula: C10H12N8O|Chemical Name: 6-(pyrrolidin-1-yl)-N-(2H-1,2,3,4-tetrazol-5-yl)pyrazine-2-carboxamide|Smiles: O=C(NC1N=NNN=1)C1=CN=CC(=N1)N1CCCC1|InChiKey: LUJDHCXCWJFNOJ-UHFFFAOYSA-N|InChi: InChI=1S/C10H12N8O/c19-9(13-10-14-16-17-15-10)7-5-11-6-8(12-7)18-3-1-2-4-18/h5-6H,1-4H2,(H2,13,14,15,16,17,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Clavulanate} site|{Clavulanate} Antibiotic|{Clavulanate} Biological Activity|{Clavulanate} In Vitro|{Clavulanate} manufacturer|{Clavulanate} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:33156798 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|The experimental asthma caused by IgE antibody in rats is inhibited by HSR-6071 (0.01-0.1 mg/kg; i.v.) in a dose-dependent manner. The bronchoconstriction mediated by IgE or IgG antibody in guinea-pigs is also prevented by HSR-6071 (0.3, 1,3 mg/kg; i.v.). HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea. HSR-6071 inhibits the IgE-mediated histamine release with an IC50 of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract.|Products are for research use only. Not for human use.|