Product Name :
CL-82198
Description:
CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression.
CAS:
307002-71-7
Molecular Weight:
338.83
Formula:
C17H23ClN2O3
Chemical Name:
N-[4-(morpholin-4-yl)butyl]-1-benzofuran-2-carboxamide hydrochloride
Smiles :
Cl.O=C(NCCCCN1CCOCC1)C1=CC2=CC=CC=C2O1
InChiKey:
PIOACXKZWXHBRB-UHFFFAOYSA-N
InChi :
InChI=1S/C17H22N2O3.ClH/c20-17(16-13-14-5-1-2-6-15(14)22-16)18-7-3-4-8-19-9-11-21-12-10-19;/h1-2,5-6,13H,3-4,7-12H2,(H,18,20);1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs.Folinic acid Autophagy CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression.Fremanezumab manufacturer |Product information|CAS Number: 307002-71-7|Molecular Weight: 338.PMID:32897165 83|Formula: C17H23ClN2O3|Chemical Name: N-[4-(morpholin-4-yl)butyl]-1-benzofuran-2-carboxamide hydrochloride|Smiles: Cl.O=C(NCCCCN1CCOCC1)C1=CC2=CC=CC=C2O1|InChiKey: PIOACXKZWXHBRB-UHFFFAOYSA-N|InChi: InChI=1S/C17H22N2O3.ClH/c20-17(16-13-14-5-1-2-6-15(14)22-16)18-7-3-4-8-19-9-11-21-12-10-19;/h1-2,5-6,13H,3-4,7-12H2,(H,18,20);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (330.72 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CL-82198 (10 μM; 24 hours) significantly reduces LS174 cell migration. CL-82198 decreases CTGF and TGF-β1 protein levels in hepatic stellate cells.|In Vivo:|CL82198 (1-10 mg/kg; i.p.; every other day for 12 weeks) prevents and decelerates MLI-induced osteoarthritis progression.|Products are for research use only. Not for human use.|