5-Azacytidine__DNA hypomethylation agent Enzalutamide
Product Name
5-Azacytidine
Description
DNA hypomethylation agent
Purity
>98% (TLC); NMR (Conforms)
CAS No.
320-67-2
Molecular Formula
C8H12N4O5
Molecular Weight
244.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 25 mg/ml DMSO or 12 mg/ml Water
Source
Synthetic
Appearance
White Solid
SMILES
C1=NC(=NC(=O)N1[[email protected]function(t,e,r,n,c,a,p){try{t=document.currentScript||function(){for(t=document.getElementsByTagName(_script_),e=t.length;e–;)if(t[e].getAttribute(_data-cfhash_))return t[e]}();if(t&&(c=t.previousSibling)){p=t.parentNode;if(a=c.getAttribute(_data-cfemail_)){for(e=__,r=_0x_+a.substr(0,2)|0,n=2;a.length-n;n+=2)e+=_%_+(_0_+(_0x_+a.substr(n,2)^r).toString(16)).slice(-2);p.replaceChild(document.createTextNode(decodeURIComponent(e)),c)}p.removeChild(t)}}catch(u){}}()/* ]]> */]2[C@@H]([C@@H]([[email protected]function(t,e,r,n,c,a,p){try{t=document.currentScript||function(){for(t=document.getElementsByTagName(_script_),e=t.length;e–;)if(t[e].getAttribute(_data-cfhash_))return t[e]}();if(t&&(c=t.previousSibling)){p=t.parentNode;if(a=c.getAttribute(_data-cfemail_)){for(e=__,r=_0x_+a.substr(0,2)|0,n=2;a.length-n;n+=2)e+=_%_+(_0_+(_0x_+a.substr(n,2)^r).toString(16)).slice(-2);p.replaceChild(document.createTextNode(decodeURIComponent(e)),c)}p.removeChild(t)}}catch(u){}}()/* ]]> */](O2)CO)O)O)N
InChI
InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
InChIKey
NMUSYJAQQFHJEW-KVTDHHQDSA-N
Safety Phrases
Classification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302- Harmful if swallowed
H350 – May cause cancer
Precautionary Statements:
P201 – Obtain special instructions before use.
P308 + P313 – If exposed or concerned: Get medical advice/attention
Cite This Product
5-Azacytidine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-345)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19110905
Alternative Names
4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; Ladakamycin; U-18496; NSC-102816; 5-AzaC
Research Areas
Cancer, Cell Signaling, Epigenetics
PubChem ID
9444
Scientific Background
DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
References
1. Schneider-Stock R., et al. (2005) J Pharmacol Exp Ther. 312(2): 525-536.
2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55.
3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75.
DNA hypomethylation agent
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302- Harmful if swallowed
H350 – May cause cancer
Precautionary Statements:
P201 – Obtain special instructions before use.
P308 + P313 – If exposed or concerned: Get medical advice/attention
2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55.
3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75.