6-Formylindolo(3,2-b)carbazole__Ah receptor ligand TAK-242
Product Name
6-Formylindolo(3,2-b)carbazole
Description
Ah receptor ligand
Purity
>95%
CAS No.
172922-91-7
Molecular Formula
C19H12N2O
Molecular Weight
284.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Ligand
Solubility
Soluble in DMSO (10 mg/ml)
Source
Synthetic
Appearance
Yellow solid
SMILES
C1=CC=C2C(=C1)C3=CC4=NC5=CC=CC=C5C4=C(C3=N2)C=O
InChI
InChI=1S/C19H10N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10H
InChIKey
OTWFDHQTFRXSAK-UHFFFAOYSA-N
Safety Phrases
Classification: Caution. Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25 – Avoid contact with skin and eyes
Cite This Product
6-Formylindolo(3,2-b)carbazole (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-383)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19110913
Alternative Names
Indolo[3,2-b]carbazole-6-carbaldehyde, FICZ
Research Areas
Cell Signaling
PubChem ID
22245026
Scientific Background
A tryptophan-derived, high affinity aryl hydrocarbon receptor ligand (Kd=7×10-11 M). Proposed to be an endogenous AhR ligand. Induces rapid and transient expression of cytochrome P450-1A1 (CYP1A1) in human cells at 100 pM.
References
1. Wei Y.D., et al. (1998) Chem. Biol. Interact. 110(1-2): 39-55.
2. Rannug U., et al. (1995) Chem. Biol. Drug. Des. 2(12): 841-855.
3. Rannug A., et al. (1987) J. Biol. Chem. 262(32): 15422-7.
Ah receptor ligand
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25 – Avoid contact with skin and eyes
2. Rannug U., et al. (1995) Chem. Biol. Drug. Des. 2(12): 841-855.
3. Rannug A., et al. (1987) J. Biol. Chem. 262(32): 15422-7.