Actinomycin D__Transcription inhibitor Fulvestrant
Product Name
Actinomycin D
Description
Transcription inhibitor
Purity
>98%
CAS No.
50-76-0
Molecular Formula
C62H86N12O16
Molecular Weight
1255.43
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 50 mM in DMSO
Source
Synthetic
Appearance
White Solid
SMILES
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
InChI
InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)3
InChIKey
RJURFGZVJUQBHK-UHFFFAOYSA-N
Safety Phrases
Classification: Very Toxic. May be fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R26/27/28 – Very Toxic by inhalation, in contact with skin and if swallowed
R36/37/38 – Irritating to eyes, respiratory system and skin
R40 – Limited evidence of a carcinogenic effect
R62 – Possible risk of impaired fertility
Hazard Phrases:
H300 – Fatal if swallowed
Precautionary Phrases:
P264 –P301 + P310
Cite This Product
Actinomycin D (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-245)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19111760
Alternative Names
2-Amino-N,N'-bis(6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Research Areas
Cancer, Apoptosis
PubChem ID
2019
Scientific Background
The actinomycins are a class of polypeptide antibiotics. Actinomycin D inhibits transcription by binding DNA at the transcription initiation complex and preventing elongation by RNA polymerase (1). Actinomycin D has been used as a chemotherapy drug (2), and an antibiotic.
References
1. Sobell H. (1985) Proc Natl Acad Sci USA. 82(16): 5328-31.
2. Turan T., et al. (2006) Int J Gynecol Cancer. 16(3): 1432-1438.
Transcription inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R26/27/28 – Very Toxic by inhalation, in contact with skin and if swallowed
R36/37/38 – Irritating to eyes, respiratory system and skin
R40 – Limited evidence of a carcinogenic effect
R62 – Possible risk of impaired fertility
Hazard Phrases:
H300 – Fatal if swallowed
Precautionary Phrases:
P264 –P301 + P310
2. Turan T., et al. (2006) Int J Gynecol Cancer. 16(3): 1432-1438.