AG 1478__EGFR kinase inhibitor Rucaparib (phosphate)
Product Name
AG 1478
Description
EGFR kinase inhibitor
Purity
>98% (HPLC)
CAS No.
153436-53-4
Molecular Formula
C16H14ClN3O2
Molecular Weight
315.8
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (10 mg/ml)
Source
Synthetic
Appearance
White to light yellow solid
SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC
InChI
InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
InChIKey
GFNNBHLJANVSQV-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
AG 1478 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-425)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19112019
Alternative Names
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine, 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
2051
Scientific Background
AG 1478 is a potent and selective inhibitor of EGFR. It does so by reducing EGF-stimulated DNA synthesis (seen in rat fibroblasts) and blocking EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction (seen in A431 cells). AG 1478 is cell-permeable and active in vivo.
References
1. Osherov N., & Levitzki A. (1994) Euro J. Biochem. 225(3): 1047–1053.
2. Miyazaki Y., et al. (1996) Biochem. Biophys. Research Comm. 226(2): 542–546.
3. Fan Z., et al. (1995) J Cell Biol. 131(1): 235–242.
EGFR kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Miyazaki Y., et al. (1996) Biochem. Biophys. Research Comm. 226(2): 542–546.
3. Fan Z., et al. (1995) J Cell Biol. 131(1): 235–242.