AG 879__NGFR kinase inhibitor Asunaprevir
Product Name
AG 879
Description
NGFR kinase inhibitor
Purity
99% (TLC)
CAS No.
148741-30-4
Molecular Formula
C18H24N2OS
Molecular Weight
316.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml)
Source
Synthetic
Appearance
Yellow solid
SMILES
CC(C1=CC(C=C(C(C)(C)C)C1=O)=CC(=C(S)N)C#N)(C)C
InChI
InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+
InChIKey
LCUMYVYIHXYBIA-FOWTUZBSSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
AG 879 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-429)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19112087
Alternative Names
Tyrphostin AG 879, α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
5487525
Scientific Background
A879 is a selective inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. It also inhibits ErbB2 and VEGFR-2.
References
1. He H., et al. (2004) Cancer Biol. Therapy. 3(1): 96–101.
2. Ohmichi M., et al. (1993) Biochem. 32(17): 4650–4658.
NGFR kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Ohmichi M., et al. (1993) Biochem. 32(17): 4650–4658.