Alsterpaullone__CDK, GSK Inhibitor Presatovir
Product Name
Alsterpaullone
Description
CDK, GSK Inhibitor
Purity
>98% (HPLC)
CAS No.
237430-03-4
Molecular Formula
C16H11N3O3
Molecular Weight
293.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO; insoluble in water or 100% ethanol
Source
Synthetic
Appearance
Yellow to brown powder
SMILES
C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)[N+](=O)[O-]
InChI
InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
InChIKey
OLUKILHGKRVDCT-UHFFFAOYSA-N
Safety Phrases
Classification:
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity – single exposure (Category 3), Respiratory system, H335
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well – ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well – ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product
Alsterpaullone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-431)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19113877
Alternative Names
9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
5005498
Scientific Background
Alsterpaullone is a potent inhibitor of CDK1/cyclin B. It is also a potent and selective inhibitor of GSK-3β and CDK5/p25. Alsterpaullone induces apoptosis by activating caspase-8 and caspase-9, followed by disruption of the mitochondrial potential. It is cell-permeable.
References
1. Zaharevitz D.W., et al. (1999). Cancer Research. 59(11): 2566–2569.
2. Lahusen T., De Siervi A., Kunick C., & Senderowicz A.M. (2003) Mol. Carcinogenesis. 36(4): 183–194.
3. Schultz C., et al. (1999) J. Med. Chem. 42(15): 2909–2919.
CDK, GSK Inhibitor
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity – single exposure (Category 3), Respiratory system, H335
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well – ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well – ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
2. Lahusen T., De Siervi A., Kunick C., & Senderowicz A.M. (2003) Mol. Carcinogenesis. 36(4): 183–194.
3. Schultz C., et al. (1999) J. Med. Chem. 42(15): 2909–2919.