AS 041164

AS 041164__PI 3-Kgamma kinase inhibitor XMU-MP-1

Product Name AS 041164
Description

PI 3-Kgamma kinase inhibitor

Purity >98% (TLC)
CAS No. 6318-41-8
Molecular Formula C11H7NO4S
Molecular Weight 249.2
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (25 mg/ml). For in vivo administration this compound was suspended in 0.5% carboxymethylcellulose/0.25% Tween 20 as a vehicle
Source Synthetic
Appearance Yellow solid
SMILES C2=C(C=C1/C(NC(S1)=O)=O)C=CC3=C2OCO3
InChI InChI=1S/C11H7NO4S/c13-10-9(17-11(14)12-10)4-6-1-2-7-8(3-6)16-5-15-7/h1-4H,5H2,(H,12,13,14)
InChIKey SDGWAUUPHUBJNQ-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.

Cite This Product AS 041164 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-433)

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19114889

Alternative Names NSC31098, 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione
Research Areas Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 233033
Scientific Background AS 041164 is a selective PI 3-Kγ isoform inhibitor. It also blocks neutrophil migration.
References 1. Ferrandi C., et al. (2007) J. Pharmacol. Exp.Ther. 322(3): 923–930.