Carnosic acid__PPARγ activator Tebipenem pivoxil
Product Name
Carnosic acid
Description
PPARγ activator
Purity
>95% (HPLC); NMR(Conforms)
CAS No.
07-09-50
Molecular Formula
C20H28O4
Molecular Weight
332.43
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Activator
Solubility
Soluble in DMSO (50 mg/ml)
Source
Synthetic
Appearance
Off white to yellow solid
SMILES
CC(C)C1=C(C(=C2C(=C1)CCC@@H3C@@2(CCCC3(C)C)C(=O)O)O)O
InChI
InChI=1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1
InChIKey
QRYRORQUOLYVBU-VBKZILBWSA-N
Safety Phrases
Classification: Caution- Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
Carnosic acid (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-362)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19117923
Alternative Names
(4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,3,4,9,10,10a-hexahydro-2H-phenanthrene-4a-carboxylic acid
Research Areas
Cancer, Apoptosis
PubChem ID
65126
Scientific Background
Carnosic acid is a benzenediol abietane diterpene naturally extracted from rosemary (Rosmarinus officinalis) and sage (Saliva officinalis). It is a potent antioxidant that inhibits NADH or NADPH induced lipid peroxidation by acting as a free radical scavenger (1). It has been found to increase cellular levels of glutathione (GSH) and prevent 6-hydroxydopamine-induced cell death in SH-SY5Y cells (2). Carnosic acid-stimulation of GSH also inhibits adipocyte differentiation (3). It has also been found to induce apoptosis (4) and inhibit the proliferation and migration of various tumor cell lines (5).
References
1. Schwarz K., Ternes W. (1992) Zeitschrift für Lebensmittel-Untersuchung und –Forschung. 195 (2): 99-103.
2. Chen J.H., et al. Chem. (2012) Res. Toxicol 25:1893.
3. Takahashi T., et al. (2009) Biochem. Biophys. Res. Commun. 382:549.
4. Kar S., et al. (2012) Apoptosis. 17:1735.
5. Barni M.V., et al. (2012) Oncol. Rep. 27:1041.
PPARγ activator
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
2. Chen J.H., et al. Chem. (2012) Res. Toxicol 25:1893.
3. Takahashi T., et al. (2009) Biochem. Biophys. Res. Commun. 382:549.
4. Kar S., et al. (2012) Apoptosis. 17:1735.
5. Barni M.V., et al. (2012) Oncol. Rep. 27:1041.