CCT241161__RAF Inhibitor Selumetinib
Product Name
CCT241161
Description
RAF Inhibitor
Purity
>98%
CAS No.
1163719-91-2
Molecular Formula
C28H27N7O3S
Molecular Weight
541.63
Storage Temperature
-20ºC
Shipping Temperature
Blue Ice or 4ºC
Product Type
Inhibitor
Solubility
Soluble in DMSO
Source
Synthetic
Appearance
White Solid
SMILES
CC(C)(C)C1=NN(C2=CC=CC=C2)C(NC(NC(C(SC)=C3)=CC=C3OC4=C5C(NC(C=N5)=O)=NC=C4)=O)=C1
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
CCT241161 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-186)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19118089
Alternative Names
1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-(methylthio)-4-((3-oxo-3,4-dihydropyrido2,3-bpyrazin-8-yl)oxy)phenyl)urea
Research Areas
Cancer, Apoptosis
Scientific Background
CCT241161, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant tumors. It is active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.03µM and 0.01µM for BRAF kinase and SRC kinase respectively.
References
1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.
RAF Inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection