DMPQ Dihydrochloride__PDGFRβ kinase inhibitor TG-101348
Product Name
DMPQ Dihydrochloride
Description
PDGFRβ kinase inhibitor
Purity
>98% (HPLC)
CAS No.
137206-97-4
Molecular Formula
C16H16ClN2O2
Molecular Weight
339.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in water
Source
Synthetic
Appearance
White to beige solid
SMILES
C1=CC(=CC=N1)C2=CC3=C(N=C2)C=C(C=C3OC)OC
InChI
InChI=1S/C16H14N2O2.2ClH/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11;;/h3-10H,1-2H3;2*1H
InChIKey
YBBAOKYVJCNJIV-UHFFFAOYSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 4)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 Harmful if swallowed.
Cite This Product
DMPQ Dihydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-441)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120928
Alternative Names
5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
45073427
Scientific Background
DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ). It displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.
References
1. Dolle R.E., et al. (1994) J. Med. Chem. 37(17): 2627–2629.
PDGFRβ kinase inhibitor
Acute toxicity, Oral (Category 4)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 Harmful if swallowed.