Etoposide__Topoisomerase II inhibitor Regorafenib
Product Name
Etoposide
Description
Topoisomerase II inhibitor
Purity
>98%
CAS No.
33419-42-0
Molecular Formula
C29H32O13
Molecular Weight
588.56
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
White solid
SMILES
CC@@H1OCC@@H2C@@H(O1)C@@H(email protected(C@@H(O2)Oemail protected3email protected4COC(=O)C@@H4C@@H(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
InChI
InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)1
InChIKey
VJJPUSNTGOMMGY-MRAJQDPKSA-N
Safety Phrases
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S53 – Avoid exposure – obtain special instruction before use
Risk Phrases:
R20/21/22 – Harmful by inhilation, in contact with skin and if swallowed
R45 – May cause cancer
R62 – Possible risk of impaired fertility
R68 – Possible risk of irreversible effects
Hazard Phrases:
H302-H350
Precautionary Phrases:
P201-P308 + P313
Cite This Product
Etoposide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-244)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19123941
Alternative Names
(5S,5aR,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro3',4':6,7naphtho2,3-d1,3dioxol-5-yl 4,6-O-(1R)-ethylidene-β-D-glucopyranoside
Research Areas
Cancer, Apoptosis
PubChem ID
36462
Scientific Background
Etoposide inhibits the enzyme topoisomerase II, which unwinds DNA, and be doing so causes the DNA strand to break. Cancer cells are then less likely to be able to repair this damage (1).
References
1. Gordaliza M., et al. (2004) Toxicon. 44(4): 441-459.
Topoisomerase II inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S53 – Avoid exposure – obtain special instruction before use
Risk Phrases:
R20/21/22 – Harmful by inhilation, in contact with skin and if swallowed
R45 – May cause cancer
R62 – Possible risk of impaired fertility
R68 – Possible risk of irreversible effects
Hazard Phrases:
H302-H350
Precautionary Phrases:
P201-P308 + P313