FCR1__FRET ratiometric fluorescence-based redox sensor GSK1324726A
Product Name
FCR1
Description
FRET ratiometric fluorescence-based redox sensor
Molecular Formula
C34H37N7O6
Molecular Weight
639
Storage Temperature
-20ºC
Shipping Temperature
Blue Ice or 4ºC
Product Type
Redox Probe
Solubility
Soluble in DMSO
Source
Synthetic
Appearance
Orange Solid
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
FCR1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-180)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19124024/
Alternative Names
7-(Diethylamino)-N-((1r,4r)-4-(2-(10-ethyl-2,4-dioxo-4,10-dihydrobenzogpteridin-3(2H)-yl)acetamido)cyclohexyl)-2-oxo-2H-chromene-3-carboxamide (FCR1)
Research Areas
Cancer, Oxidative Stress
Scientific Background
FCR1 or flavin coumarin redox sensor 1, is a novel ratiometric fluorescent redox sensor utilized in fluorescence lifetime imaging microscopy and flow cytometry. In the oxidized form, excitation of FCR1 at 405nm results in a green fluorescence with max emissions at 525nm. Treatment with a mild reducing agent (including sodium cyanoborohydride, DTT, and glutathione) reduces the flavin thereby decreasing the green fluorescence intensity, and increasing the blue. Re-oxidation can be achieved using mild oxidizing agents. In general, the FCR1 probe can be used to observe changes in oxidative capacity without interference from background effects.
References
1. Kaur A., Haghighatbin M.A., Hogan C.F., and New E.J. (2015) Chem. Commun. Epub.
FRET ratiometric fluorescence-based redox sensor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection