Felodipine__L-type Ca channel blocker Celastrol
Product Name
Felodipine
Description
L-type Ca channel blocker
Purity
>98% (TLC); NMR (Conforms)
CAS No.
72509-76-3
Molecular Formula
C18H19Cl2NO4
Molecular Weight
384.25
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Source
Synthetic
Appearance
Light Yellow Solid
SMILES
CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
InChI
InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey
RZTAMFZIAATZDJ-UHFFFAOYSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with shin and eyes
Risk Phrases:
R20/21/22 – Harmful by inhilation, in contact with skin and if swallowed
R62 – Possible risk of impaired fertility
Hazard Phrases:
H302
Cite This Product
Felodipine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-323)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19124046
Alternative Names
Ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate, Plendil
Research Areas
Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels
PubChem ID
3333
Scientific Background
Felodipine is an L-type Ca2+ channel blocker (1). In isolated rat ventricular myocytes, using a whole-cell patch-clamp technique, it displays a Ki of 11 nM (2). It is a clinically useful antihypertensive agent (3) which attenuates the hypertrophic effect of cyclosporine on transplanted hearts (4).
References
1. Furakawa T., et al. (2005) J Cardiovasc. Pharmacol. 45(3): 241-246.
2. Zahradnikova Z., Minarovic I., Zahradnik I. (2007) J Pharmacol Exp. Ther. 322(2): 638-645.
3. Manzo B.A., Matalka M.S., Ravnan S.L. (2003) Pharmacotherapy. 23(11): 1508-1512.
4. Schwitter J., et al. (1999) J Heart Lung Transplant. 18(10): 1003-1013.
L-type Ca channel blocker
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with shin and eyes
Risk Phrases:
R20/21/22 – Harmful by inhilation, in contact with skin and if swallowed
R62 – Possible risk of impaired fertility
Hazard Phrases:
H302
2. Zahradnikova Z., Minarovic I., Zahradnik I. (2007) J Pharmacol Exp. Ther. 322(2): 638-645.
3. Manzo B.A., Matalka M.S., Ravnan S.L. (2003) Pharmacotherapy. 23(11): 1508-1512.
4. Schwitter J., et al. (1999) J Heart Lung Transplant. 18(10): 1003-1013.