FK-866 HCl__NAD biosynthesis inhibitor Ombitasvir
Product Name
FK-866 HCl
Description
NAD biosynthesis inhibitor
Purity
>98% (TLC); NMR (Conforms)
CAS No.
658084-64-1
Molecular Formula
C24H29N3O2•HCl
Molecular Weight
428
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 40 mg/ml Water
Source
Synthetic
Appearance
White Solid
SMILES
C1CN(CCC1CCCCNC(=O)/C=C/C2=CN=CC=C2)C(=O)C3=CC=CC=C3
InChI
InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
InChIKey
KPBNHDGDUADAGP-VAWYXSNFSA-N
Safety Phrases
Classification: Caution- Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed.
Cite This Product
FK-866 HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-354)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19124506
Alternative Names
(E)-N-4-(1-benzoylpiperidin-4-yl)butyl-3-(pyridin-3-yl)acrylamide, FK866 hydrochloride hydrate, K22.175
Research Areas
Cell Signaling, Epigenetics
PubChem ID
6914657
Scientific Background
Nicotinamide phosphoribosyltransferase inhibitor (Ki=0.4 nM). Induces tumor cell apoptosis. Extends lifespan of human cells. Cell permeable.
References
1. Hasmann M., et al. (2003) Cancer Res. 63: 7436.
2. van der Veer E., et al. (2007) J. Biol. Chem. 282: 10841.
NAD biosynthesis inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed.
2. van der Veer E., et al. (2007) J. Biol. Chem. 282: 10841.