Garcinol__HAT inhibitor AICAR
Product Name
Garcinol
Description
HAT inhibitor
Purity
>98% (TLC); NMR (Conforms)
CAS No.
78824-30-3
Molecular Formula
C38H50O6
Molecular Weight
602.8
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
Source
Synthetic
Appearance
Yellow solid
SMILES
CC(=CCC@@H1CC@@2(C(=C(C(=O)C@@(C2=O)(C1(C)C)CC=C(C)C)C(=O)C3=CC(=C(C=C3)O)O)O)Cemail protected(CC=C(C)C)C(=C)C)C
InChI
InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21
InChIKey
DTTONLKLWRTCAB-UDFURZHRSA-N
Safety Phrases
Classification: Caution- Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
Garcinol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-355)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19125160
Alternative Names
Camboginol, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl-bicyclo3.3.1non-3-ene-2,9-dione
Research Areas
Cell Signaling, Epigenetics
PubChem ID
5490884
Scientific Background
Potent inhibitor of histone acetyl transferases p300 (IC50=7 mM) and pCAF (IC50=5 mM) (1). Induces apoptosis in various cell lines (2). Promotes expansion of human hematopoietic stem cells(3). Cell permeable.
References
1. Balasubramanyam K., et al., (2004) J. Biol. Chem. 279: 33716.
2. Parasramka M.A., et al. (2011) Nutr. Cancer. 63: 456.
3. Nishino T., et al. (2011) Nutr. PLoS One 6: e24298.
HAT inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
2. Parasramka M.A., et al. (2011) Nutr. Cancer. 63: 456.
3. Nishino T., et al. (2011) Nutr. PLoS One 6: e24298.