Gefitinib__EGFR Kinase inhibitor Savolitinib
Product Name
Gefitinib
Description
EGFR Kinase inhibitor
Purity
>99%
CAS No.
184475-35-2
Molecular Formula
C22H24ClFN4O3
Molecular Weight
446.9
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C)
Source
Synthetic
Appearance
Solid
SMILES
C1=C3C(=CC(=C1OC)OCCCN2CCOCC2)C(=NC=N3)NC4=CC=C(C(=C4)Cl)F
InChI
InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChIKey
XGALLCVXEZPNRQ-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Gefitinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-445)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19125249
Alternative Names
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
123631
Scientific Background
Gefitinib is a selective inhibitor of EGFR tyrosine kinase by blocking EGFR autophosphorylation.
References
1. Ciardiello F., et al. (2000) Clin. Cancer Res. 6(5): 2053–2063.
EGFR Kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.