Hypericin

Hypericin__Protein kinase C inhibitor Siponimod

Product Name	Hypericin
Description	Protein kinase C inhibitor
Purity	>98%
CAS No.	548-04-9
Molecular Formula	C30H16O8
Molecular Weight	504.45

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 10 mM in ethanol and to 50 mM in DMSO
Source	Synthetic
Appearance	Dark Red Solid
SMILES	CC1=CC(=C2C3=C4C5=C(C(=CC(=C5C2=O)O)O)C6=C7C4=C8C(=C13)C(=CC(=C8C(=O)C7=C(C=C6O)O)O)C)O
InChI	InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)2
InChIKey	BTXNYTINYBABQR-UHFFFAOYSA-N
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	Hypericin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-250)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19132562

Alternative Names	1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro1,10,9,8-opqraperylene-7,14-dione
Research Areas	Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
PubChem ID	5281051
Scientific Background	Hypericin is a naphtodianthrone that acts as an antibiotic and non-specific kinase inhibitor. It inhibits the action of dopamine beta-hydroxylase, leading to increased dopamine levels. Hypericin can also cause photosensitivity when ingested beyond threshold. And becase it also accumulates in cancerous tissues, it can be used as an indicator of cancerous cells (1, 2).
References	1. Hopfner M., et al. (2003) Int J Colorectal Dis. 18(3): 239-247. 2. Agostinis, et al. (2002) Int J Biochem Cell Biol. 34: 221.