Isradipine

Isradipine__L-type Ca channel blocker HG-9-91-02

Product Name	Isradipine
Description	L-type Ca channel blocker
Purity	>98%
CAS No.	75695-93-1
Molecular Formula	C19H21N3O5
Molecular Weight	371.39

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 50 mM in DMSO and to 20 mM in ethanol
Source	Synthetic
Appearance	Yellow Crystalline Solid
SMILES	CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
InChI	InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
InChIKey	HMJIYCCIJYRONP-UHFFFAOYSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302-H315-H317-H318-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338
Cite This Product	Isradipine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-314)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19133256

Alternative Names	Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate, PN 200-110
Research Areas	Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels
PubChem ID	3784
Scientific Background	Isradipine is a calcium channel blocker of the dihydropyridine class. It is usually used in the treatment of high blood pressure because of its anti-hypertensive properties in vivo (1). Recent studies suggest a potential use for Parkinson’s disease (2).
References	1. Wada Y., Satoh K., Taira N. (1985) J Cardiovasc Pharmacol. 7(1): 190-196. 2. Chan C.S., et al. (2007) Nature. 447: 1081-1086.