K252B__Kinase inhibitor BI 224437
Product Name
K252B
Description
Kinase inhibitor
Purity
>98% (HPLC)
CAS No.
99570-78-2
Molecular Formula
C26H19N3O5
Molecular Weight
453.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml)
Source
Synthetic
Appearance
White solid
SMILES
CC@12C@@(Cemail protected(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
InChI
InChI=1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)/t17-,25+,26+/m1/s1
InChIKey
AMSOPBXQXSAAAC-PLZPTFKGSA-N
Safety Phrases
Classification:
Flammable liquids (Category 4), H227
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H227 Combustible liquid
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol – resistant foam for extinction.
P403 + P235 Store in a well – ventilated place. Keep cool.
P501 Dispose of contents/ container to an approved waste disposal plant
Cite This Product
K252B (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-456)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19134433
Alternative Names
(9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo1,2,3-fg:3',2',1'-klpyrrolo3,4-i1,6benzodiazocine-10-carboxylic acid
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
9981344
Scientific Background
K252B is a non-selective, protein kinase inhibitor. It inhibits CaMKII, MYLK, PKA, PKC, and cGKI. It acts by binding to the ATP binding domain of the kinase. K252B is cell permeable.
References
1. Nakanishi S., Matsuda Y., Iwahashi K., & Kase H. (1986) J. Antibiotics 39(8): 1066–1071.
2. Teshima R., et al. (1997) J. Immun. 159(2): 964–969.
3. Knüsel B., et al. (1992) J. Neurochem. 59(2): 715–722.
Kinase inhibitor
Flammable liquids (Category 4), H227
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H227 Combustible liquid
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol – resistant foam for extinction.
P403 + P235 Store in a well – ventilated place. Keep cool.
P501 Dispose of contents/ container to an approved waste disposal plant
2. Teshima R., et al. (1997) J. Immun. 159(2): 964–969.
3. Knüsel B., et al. (1992) J. Neurochem. 59(2): 715–722.