LY 294002__PI 3-Kinase inhibitor PNU-159683
Product Name
LY 294002
Description
PI 3-Kinase inhibitor
Purity
>98%
CAS No.
154447-36-6
Molecular Formula
C19H17NO3•HCl
Molecular Weight
343.81
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 5 mM in ethanol and to 25 mM in DMSO
Source
Synthetic
Appearance
White Crystalline Solid
SMILES
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
InChI
InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChIKey
CZQHHVNHHHRRDU-UHFFFAOYSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
LY 294002 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-252)
Alternative Names
2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-one
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
PubChem ID
3973
Scientific Background
LY294002 is a potent inhibitor of PI3Ks. It inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo (1).
References
1. Vlahos, et al. (1994) J Biol Chem. 269: 5241.
PI 3-Kinase inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection