Lysophosphatidic Acid, Sodium Salt__Autophagy inhibitor CC-931
Product Name
Lysophosphatidic Acid, Sodium Salt
Description
Autophagy inhibitor
Purity
>98%
CAS No.
22556-62-3
Molecular Formula
C21H41O7P*Na
Molecular Weight
458.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (1 mg/ml) and warm water (10 mg/ml).
Source
Synthetic
Appearance
White powder.
SMILES
C(OP(=O)(O)O)C(O)COC(=O)CCCCCCCC=C/CCCCCCCC
InChI
InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-/t20-/m1/s1
InChIKey
WRGQSWVCFNIUNZ-GDCKJWNLSA-N
Safety Phrases
Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Lysophosphatidic Acid, Sodium Salt (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-403)
Alternative Names
Oleoyl-lysophosphatidic acid sodium salt
Research Areas
Cancer, Autophagy
PubChem ID
5311263
Scientific Background
Oleoyl-lysophosphatidic acid is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. It has been shown to induce cellular functions such as cell proliferation and migration, and ICAM-1, IL-8 and MCP-1 expression. Lysophosphatidic acid has also been observed to inhibit autophagy in cells under starvation conditions by inhibiting autophagosome formation.
References
1. van Corven E.J., et al. (1992) Biochem J. 281(Pt 1): 163-9.
2. Chang C.L., et al. (2007) Autophagy. 3(3): 268-70.
Autophagy inhibitor
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Chang C.L., et al. (2007) Autophagy. 3(3): 268-70.