MLN4924__NEDD8 activating enzyme inhibitor Ebselen
Product Name
MLN4924
Description
NEDD8 activating enzyme inhibitor
Purity
>98%
CAS No.
905579-51-3
Molecular Formula
C21H25N5O4S
Molecular Weight
443.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 10 mg/ml DMSO
Source
Synthetic
Appearance
White Powder
SMILES
C1CC2=CC=CC=C2email protected1NC3=C4C=CN(C4=NC=N3)C@@H5Cemail protected(email protected(C5)O)COS(=O)(=O)N
InChI
InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,
InChIKey
MPUQHZXIXSTTDU-QXGSTGNESA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
mlN4924 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-331)
Alternative Names
(1S,2S,4R)-4-{4-(1S)-2,3-Dihydro-1H-inden-1-ylamino-7H-pyrrolo2,3-dpyrimidin-7-yl}-2-hydroxycyclopentylmethyl sulfamate, Sulfamic acid
Research Areas
Cancer, Apoptosis
PubChem ID
16720766
Scientific Background
Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. It suppresses the growth of human tumor xenografts in mice. Cell permeable.
References
1. Soucy T.A., et al. (2009) Nature. 458:732.
2. Milhollen M.A., et al. (2010) Blood. 116:1515.
NEDD8 activating enzyme inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
2. Milhollen M.A., et al. (2010) Blood. 116:1515.