N,N-Dimethylsphingosine__Kinase inhibitor GDC-0033
Product Name
N,N-Dimethylsphingosine
Description
Kinase inhibitor
Purity
>98%
CAS No.
119567-63-4
Molecular Formula
C20H41NO2
Molecular Weight
327.6
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml)
Source
Synthetic
Appearance
White to off-white waxy solid, or viscous oil
SMILES
CCCCCCCCCCCCC/C=C/email protected(email protected(CO)N(C)C)O
InChI
InChI=1S/C20H37NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(25)19(16-22)21(17-23)18-24/h14-15,17-20,22,25H,2-13,16H2,
InChIKey
XPDYLGZWYWKOFM-PPQGUHKJSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22- Harmful by inhalation, in contact with skin and if swallowed
Cite This Product
N,N-Dimethylsphingosine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-235)
Alternative Names
(2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
PubChem ID
6438166
Scientific Background
N,N-dimethylsphingosine is a potent and specific inhibitor of sphingosine kinase. It is a natural metabolite of sphiongosine in some cancel cell lines and tissues (1). It also induces apoptosis, but it is not an inhibitor of protein kinase C (2).
References
1. Yatomi Y., et al. (1996) Biochem. 35: 626-633.
2. Sweeny E.A., et al. (1996) Int J Cancer. 66(3): 358-366.
Kinase inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22- Harmful by inhalation, in contact with skin and if swallowed
2. Sweeny E.A., et al. (1996) Int J Cancer. 66(3): 358-366.