Niclosamide

Niclosamide__Autophagy inducer I-BET152

Product Name Niclosamide
Description

Autophagy inducer

Purity >98% (TLC); NMR (Conforms)
CAS No. 50-65-7
Molecular Formula C13H8Cl2N2O4
Molecular Weight 327.12
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble to 25 mM in ethanol and to 10 mM in DMSO
Source Synthetic
Appearance Pale yellow solid
SMILES C2=C(C(NC1=C(C=C(N+(=O)O-)C=C1)Cl)=O)C(=CC=C2Cl)O
InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChIKey RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Safety Phrases Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Niclosamide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-406)
Alternative Names 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Research Areas Cancer, Autophagy
PubChem ID 4477
Scientific Background Niclosamide is part of the anthelmintics drug class, which are used to treat tapeworm infections in humans. Niclosamide has been shown to selectively inhibit the Stat-3 signalling pathway, specifically by inhibiting its activation, nuclear translocation and transcriptional activity. It has also been reported that Niclosamide inhibits mTORC1, thereby inducing autophagy and increasing the formation of autophagosomes.
References 1. Pan J.X., et al. (2012) Chin J Cancer. 31(4): 178-84.