DAPT

DAPT__γ-secretase inhibitor SCH 527123

Product Name DAPT
Description

γ-secretase inhibitor
Purity >99%
CAS No. 208255-80-5
Molecular Formula C23H26F2N2O4
Molecular Weight 432.46
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance White to off-white powder
SMILES email protected(NC(=O)C@@H(NC(=O)CC1=CC(=CC(=C1)F)F)C)(C2=CC=CC=C2)C(OC(C)(C)C)=O
InChI InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChIKey DWJXYEABWRJFSP-XOBRGWDASA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product DAPT (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-378)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120266

Alternative Names N-(3,5-Difluorophenyl)acetyl-L-al­anyl-2-phenylglycine-1,1-dimethylethyl ester
Research Areas Cell Signaling, Neuroscience
PubChem ID 5311272
Scientific Background Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.
References 1. Dovey H.F., et al. (2001) J. Neurochem. 76(1): 173-81.
2. De Smedt M., et al. (2005) Blood. 106(10): 3498-506.
3. Kanungo J., et al. (2008) J. Neurochem. 106(5): 2236-48.

D-LAP5.Na

D-LAP5.Na__NMDA receptor antagonist Romidepsin

Product Name D-LAP5.Na
Description

NMDA receptor antagonist
Purity >99.0
CAS No. 1303993-72-7
Molecular Formula C5H12NO5P•Na
Molecular Weight 219.11
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Antagonist
Solubility Soluble to 100 mM in water
Source Synthetic
Appearance White solid
SMILES C(P(O)(O)=O)CCC(C(O)=O)N
Safety Phrases Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product D-LAP5.Na (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-414)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120261

Alternative Names DL-amino-5-phosphonopentaoic acid sodium salt
Research Areas Glutamate Receptors, Ion Channels, Neuroscience, Neurotransmitter Receptors, NMDA Receptors
Scientific Background DLAP5 is a racemic mixture. It is used widely as a potent and selective NMDA receptor antagonist. It represents the active enantiomer form of AP5 (2-amino-5-phosphonopentanoic acid).
References 1. Davies J., & Watkins J. (1982) Brain Res. 378-86.
2. Schulte M., Roon R., Chalmers D., Sunter D., & Koerner J. (1994) Brain Res. 203-7.

D-LAP5

D-LAP5__NMDA receptor antagonist Entrectinib

Product Name D-LAP5
Description

NMDA receptor antagonist
Purity >99.0
CAS No. 76326-31-3
Molecular Formula C5H12NO5P
Molecular Weight 197.13
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Antagonist
Solubility Soluble to 10 mM in water and to 100 mM in 1eq. NaOH
Source Synthetic
Appearance White solid
SMILES C(P(O)(O)=O)CCC(C(O)=O)N
InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
InChIKey VOROEQBFPPIACJ-UHFFFAOYSA-N
Safety Phrases Classification: D2B Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product D-LAP5 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-413)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120141

Alternative Names DL-amino-5-phosphonopentaoic acid
Research Areas Glutamate Receptors, Ion Channels, Neuroscience, Neurotransmitter Receptors, NMDA Receptors
PubChem ID 1216
Scientific Background DLAP5 is a racemic mixture. It is used widely as a potent and selective NMDA receptor antagonist. It represents the active enantiomer form of AP5 (2-amino-5-phosphonopentanoic acid).
References 1. Davies J., & Watkins J. (1982) Brain Res. 378-86.
2. Schulte M., Roon R., Chalmers D., Sunter D., & Koerner J. (1994) Brain Res. 203-7.

D-AP5.Na

D-AP5.Na__NMDA receptor antagonist OTS-964

Product Name D-AP5.Na
Description

NMDA receptor antagonist
Purity >99.5
CAS No. 14375-45-2
Molecular Formula C5H12NO5P.Na
Molecular Weight 219.11
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Antagonist
Solubility Soluble in 1 M NH4OH (50 mg/ml); water (9 mg/ml).
Source Synthetic
Appearance White solid
SMILES C@@H(NH3+)(CCCP(O-)(O-)=O)C(O-)=O
Safety Phrases Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product D-AP5.Na (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-412)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120130

Alternative Names D-amino-5-phosphonopentaoic acid sodium salt
Research Areas Glutamate Receptors, Ion Channels, Neuroscience, Neurotransmitter Receptors, NMDA Receptors
Scientific Background DAP5 is used widely as a potent and selective NMDA receptor antagonist. It represents the active enantiomer form of AP5 (2-amino-5-phosphonopentanoic acid).
References 1. Davies J., & Watkins J. (1982) Brain Res. 378-86.
2. Schulte M., Roon R., Chalmers D., Sunter D., & Koerner J. (1994) Brain Res. 203-7.

D-AP5

D-AP5__NMDA receptor antagonist PLX7904

Product Name D-AP5
Description

NMDA receptor antagonist
Purity >99.5
CAS No. 79055-68-8
Molecular Formula C5H12NO5P
Molecular Weight 197.13
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Antagonist
Solubility Soluble in 100 mM water
Source Synthetic
Appearance White solid
SMILES C@@H(NH3+)(CCCP(O-)(O-)=O)C(O-)=O
InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
InChIKey VOROEQBFPPIACJ-SCSAIBSYSA-N
Safety Phrases Classification: D2B Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product D-AP5 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-411)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120117

Alternative Names D-amino-5-phosphonopentaoic acid
Research Areas Glutamate Receptors, Ion Channels, Neuroscience, Neurotransmitter Receptors, NMDA Receptors
PubChem ID 135342
Scientific Background DAP5 is used widely as a potent and selective NMDA receptor antagonist. It represents the active enantiomer form of AP5 (2-amino-5-phosphonopentanoic acid).
References 1. Davies J., & Watkins J. (1982) Brain Res. 378-86.
2. Schulte M., Roon R., Chalmers D., Sunter D., & Koerner J. (1994) Brain Res. 203-7.

CZC 54252 Hydrochloride

CZC 54252 Hydrochloride__LRRK2 inhibitor Firategrast

Product Name CZC 54252 Hydrochloride
Description

LRRK2 inhibitor
Purity >98%
CAS No. 1191911-27-9, 1330003-04-7
Molecular Formula C22H26Cl2N6O4S
Molecular Weight 541.5
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance Yellow solid
SMILES COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl
InChI InChI=1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H
InChIKey KWCBHUPLQMUKAF-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product CZC 54252 Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-439)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120115

Alternative Names N-{2-(5-Chloro-2-{2-methoxy-4-(4-morpholinyl)phenylamino}-4-pyrimidinyl)aminophenyl}methanesulfonamide hydrochloride
Research Areas Cell Signaling
Scientific Background CZC 54252 Hydrochloride is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor.
References 1. Kramer T., Lo Monte F., Göring S., Okala Amombo G.M., & Schmidt B. (2012) ACS Chem. Neuro. 3(3): 151–160.

Anti-Cytochrome P450 Reductase Antibody

Anti-Cytochrome P450 Reductase Antibody__Rabbit Anti-Rat Cytochrome P450 Reductase Polyclonal Bortezomib

Product Name Cytochrome P450 Reductase Antibody
Description

Rabbit Anti-Rat Cytochrome P450 Reductase Polyclonal
Species Reactivity Human, Mouse, Rat
Applications ,
WB
,
IHC
,
ICC/IF
Antibody Dilution WB (1:1000), ICC/IF (1:60); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Rat
Immunogen Rat native full-length Cytochrome P450 Reductase purified from liver tissue
Concentration 1 mg/ml
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

APC (Allophycocyanin)
Overview:

  • High quantum yield
  • Large phycobiliprotein
  • 6 chromophores per molecule
  • Isolated from red algae
  • Molecular Weight: 105 kDa

APC Datasheet

  APC Fluorophore Absorption and Emission Spectrum Optical Properties:

λex = 650 nm

λem = 660 nm

εmax = 7.0×105

Φf = 0.68

Brightness = 476

Laser = 594 or 633 nm

Filter set = Cy®5

 

  ATTO 390
Overview:

  • High fluorescence yield
  • Large Stokes-shift (89 nm)
  • Good photostability
  • Moderately hydrophilic
  • Good solubility in polar solvents
  • Coumarin derivate, uncharged
  • Low molar mass: 343.42 g/mol 

ATTO 390 Datasheet

 ATTO 390 Fluorescent Dye Excitation and Emission Spectra Optical Properties:

λex = 390 nm

λem = 479 nm

εmax = 2.4×104

Φf = 0.90

τfl = 5.0 ns

Brightness = 21.6

Laser = 365 or 405 nm

 

  ATTO 488
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation
  • New dye with net charge of -1
  • Molar Mass: 804 g/mol 

ATTO 488 Datasheet

   ATTO 488 Fluorophore Excitation and Emission Spectra Optical Properties:

λex = 501 nm

λem = 523 nm

εmax = 9.0×104

Φf = 0.80

τfl = 4.1 ns

Brightness = 72

Laser = 488 nm

Filter set = FITC

 

 ATTO 565
Overview:

  • High fluorescence yield
  • High thermal and photostability
  • Good solubility in polar solvents
  • Excellent solubility in water
  • Very little aggregation
  • Rhodamine dye derivative
  • Molar Mass: 611 g/mol

ATTO 565 Datasheet

  ATTO 565 Fluorophore Excitation and Emission Spectra Optical Properties:

λex = 563 nm

λem = 592 nm

εmax = 1.2×105

Φf = 0.9

τfl = 3.4 n

Brightness = 10

Laser = 532 nm

Filter set = TRITC

 

 ATTO 594
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation
  • New dye with net charge of -1
  • Molar Mass: 1137 g/mol

ATTO 594 Datasheet

  ATTO 594 Fluorophore Excitation and Emission Spectrum Optical Properties:

λex = 601 nm

λem = 627 nm

εmax = 1.2×105

Φf = 0.85

τfl = 3.5 ns

Brightness = 102

Laser = 594 nm

Filter set = Texas Red®

 

 ATTO 633
Overview:

  • High fluorescence yield
  • High thermal and photostability
  • Moderately hydrophilic
  • Good solubility in polar solvents
  • Stable at pH 4 – 11
  • Cationic dye, perchlorate salt
  • Molar Mass: 652.2 g/mol

ATTO 633 Datasheet

 ATTO 633 Fluorophore Absorption and Emission Spectrum Optical Properties:

λex = 629 nm

λem = 657 nm

εmax = 1.3×105

Φf = 0.64

τfl = 3.2 ns

Brightness = 83.2

Laser = 633 nm

Filter set = Cy®5

 

 ATTO 655
Overview:

  • High fluorescence yield
  • High thermal and photostability
  • Excellent ozone resistance
  • Quenched by electron donors
  • Very hydrophilic
  • Good solubility in polar solvents
  • Zwitterionic dye
  • Molar Mass: 634 g/mol

ATTO 655 Datasheet

 ATTO 655 Fluorophore Absorption and Emission Spectrum Optical Properties:

λex = 663 nm

λem = 684 nm

εmax = 1.25×105

Φf = 0.30

τfl = 1.8 ns

Brightness = 37.5

Laser = 633 – 647 nm

Filter set = Cy®5

 

 ATTO 680
Overview:

  • High fluorescence yield
  • Excellent thermal and photostability
  • Quenched by electron donors
  • Very hydrophilic
  • Good solubility in polar solvents
  • Zwitterionic dye
  • Molar Mass: 631 g/mol

ATTO 680 Datasheet

  ATTO 680 Fluorophore Absorption and Emission Spectrum Optical Properties:

λex = 680 nm

λem = 700 nm

εmax = 1.25×105

Φf = 0.30

τfl = 1.7 ns

Brightness = 37.5

Laser = 633 – 676 nm

Filter set = Cy®5.5

 

 ATTO 700
Overview:

  • High fluorescence yield
  • Excellent thermal and photostability
  • Quenched by electron donors
  • Very hydrophilic
  • Good solubility in polar solvents
  • Zwitterionic dye
  • Molar Mass: 575 g/mol

ATTO 700 Datasheet

  ATTO 700 Fluorophore Absorption and Emission Spectrum Optical Properties:

λex = 700 nm

λem = 719 nm

εmax = 1.25×105

Φf = 0.25

τfl = 1.6 ns

Brightness = 31.3

Laser = 676 nm

Filter set = Cy®5.5

 

  FITC (Fluorescein)
Overview:

  • Excellent fluorescence quantum yield
  • High rate of photobleaching
  • Good solubility in water
  • Broad emission spectrum
  • pH dependent spectra
  • Molecular formula: C20H12O5
  • Molar mass: 332.3 g/mol

FITC-Fluorescent-conjugate

 FITC Fluorescein Fluorophore Excitation and Emission Spectra Optical Properties:

λex = 494 nm

λem = 520 nm

εmax = 7.3×104

Φf = 0.92

τfl = 5.0 ns

Brightness = 67.2

Laser = 488 nm

Filter set = FITC

 

 PE/ATTO 594
PE/ATTO 594 is a tandem conjugate, where PE is excited at 535 nm and transfers energy to ATTO 594 via FRET (fluorescence resonance energy transfer), which emits at 627 nm.
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation

PE/ATTO 594 Datasheet

 PE-ATTO 594 Fluorophore Conjugate Excitation and Emission Spectra Optical Properties:

λex = 535 nm

λem = 627 nm

Laser = 488 to 561 nm

 

 PerCP 
Overview:

  • Peridinin-Chlorophyll-Protein Complex
  • Small phycobiliprotein
  • Isolated from red algae
  • Large stokes shift (195 nm)
  • Molecular Weight: 35 kDa

PerCP Datasheet

  PerCP Fluorophore Absorption and Emission Spectrum Optical Properties:

λex = 482 nm

λem = 677 nm

εmax = 1.96 x 106

Laser = 488 nm

 

  R-PE (R-Phycoerythrin)
Overview:

  • Broad excitation spectrum
  • High quantum yield
  • Photostable
  • Member of the phycobiliprotein family
  • Isolated from red algae
  • Excellent solubility in water
  • Molecular Weight: 250 kDa

R-PE Datasheet

  R-PE Fluorophore Excitation and Emission Spectra Optical Properties:

λex = 565 nm

λem = 575 nm

εmax = 2.0×106

Φf = 0.84

Brightness = 1.68 x 103

Laser = 488 to 561 nm

Filter set = TRITC

 

AP (Alkaline Phosphatase)

Properties:

  • Broad enzymatic activity for phosphate esters of alcohols, amines, pyrophosphate, and phenols
  • Commonly used to dephosphorylate the 5’-termini of DNA and RNA to prevent self-ligation
  • Catalyzes the conversion of:
    • Chromogenic substrates (e.g. pNPP, naphthol AS-TR phosphate, BCIP) into coloured products
    • Fluorogenic substrates (e.g. 4-methylumbelliferyl phosphate) into fluorescent products
  • Molecular weight: 140 kDa
  • Applications: Western blot, immunohistochemistry, and ELISA

AP Datasheet

HRP (Horseradish peroxidase)

Properties:

  • Enzymatic activity is used to amplify weak signals and increase visibility of a target
  • Readily combines with hydrogen peroxide (H2O2) to form HRP-H2O2 complex which can oxidize various hydrogen donors
  • Catalyzes the conversion of:
    • Chromogenic substrates (e.g. TMB, DAB, ABTS) into coloured products
    • Chemiluminescent substrates (e.g. luminol and isoluminol) into light emitting products via enhanced chemiluminescence (ECL)
    • Fluorogenic substrates (e.g. tyramine, homovanillic acid, and 4-hydroxyphenyl acetic acid) into fluorescent products
  • High turnover rate enables rapid generation of a strong signal
  • 44 kDa glycoprotein
  • Extinction coefficient: 100 (403 nm)
  • Applications: Western blot, immunohistochemistry, and ELISA

HRP Datasheet

BiotinBiotin Conjugate Structure

Properties:

  • Binds tetrameric avidin proteins including Streptavidin and neuravidin with very high affinity
  • Molar mass: 244.31 g/mol
  • Formula: C10H16N2O3S
  • Applications: Western blot, immunohistochemistry, and ELISA

Biotin Datasheet

Streptavidin

Properties:

  • Homo-tetrameric protein purified from Streptomyces avidinii which binds four biotin molecules with extremely high affinity
  • Molecular weight: 53 kDa
  • Formula: C10H16N2O3S
  • Applications: Western blot, immunohistochemistry, and ELISA

Streptavidin Datasheet
Storage Buffer PBS pH 7.4, 50% glycerol, 0.09% sodium azide
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Protein A purified
Clonality Polyclonal
Specificity Detects ~77kDa.
Cite This Product Rabbit Anti-Rat Cytochrome P450 Reductase Polyclonal (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPC-210)
Certificate of Analysis 1 µg/ml of SPC-210 was sufficient for detection of Cytochrome P450 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120092

Alternative Names Cytochrome C Reductase Antibody, CCR Antibody, CPR Antibody, P450R Antibody, CYPOR Antibody, DKFZp686G04235 Antibody, FLJ26468 Antibody, NADPH Cytochrome Antibody, P450 Reductase Antibody, NADPH dependent cytochrome P450 reductase Antibody, NADPH-cytochrome P450 reductase Antibody, P450 (cytochrome) oxidoreductase Antibody, P450 Cytochrome Oxidoreductase Antibody, P450R Antibody, POR Antibody
Research Areas Cancer, Heat Shock, Cardiovascular System
Cellular Localization Endoplasmic Reticulum, Endoplasmic reticulum membrane, Microsome
Accession Number NP_113764.1
Gene ID 29441
Swiss Prot P00388
Scientific Background Cytochrome P450 Reductase is an enyme that is required for the transfer of electrons from NADPH to cytochrome P450 in microsomes. It has also been found to transfer electrons to Heme oxygenase and cytochrome B5. Cytochrome P450 Reductase is found localized to the endoplasmic reticulum membrane, tethered by its hydrophobic N-terminal tail. Mutations in the gene encoding Cytochrome P450 Reductase (POR) have been found to cause congenital adrenal hyperplasia, Antley-Bixler syndrome, amenorrhea and disordered steroidogenesis.
References 1. Pandey A.V. and Flück C.E. (2013). Pharmacology & therapeutics 138 (2): 229–54.
2. Jensen K. and Møller BL (2010). Phytochemistry 71 (2-3): 132–41.
3. Flück C.E. et al. (2004). Nature Genetics 36 (3): 228–230.

Cytochalasin D

Cytochalasin D__Actin polymerization inhibitor SCH772984

Product Name Cytochalasin D
Description

Actin polymerization inhibitor
Purity >98% (TLC); NMR (Conforms)
CAS No. 22144-77-0
Molecular Formula C30H37NO6
Molecular Weight 507.63
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 10 mM in ethanol and to 50 mM in DMSO
Source Synthetic
Appearance White Solid
SMILES Cemail protected1C/C=C/email protected2C@@H(C(=C)email protected(C@@H3C@@2(C@@H(/C=C/email protected(C1)C)OC(=O)C)C(=O)Nemail protected3CC4=CC=CC=C4)C)O
InChI InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,3
InChIKey SDZRWUKZFQQKKV-BBXOWAOSSA-N
Safety Phrases Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62 – Possible risk of impaired fertility
R68 – Possible risk of irreversible effects
Hazard Phrases:
H300-H361
Precautionary Phrases:
P264-P281-P301 + P310
Cite This Product Cytochalasin D (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-241)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120088

Alternative Names (3S,3aR,4S,6S,6aR,7E,10S,12S,13E,15R,15aR)-3-Benzyl-6-hydroxy-4,10,12-trimethyl-5-methylene-1-oxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundecadisoindol-15-yl acetate, Zygosporin A
Research Areas Cancer, Apoptosis
PubChem ID 5458428
Scientific Background Cytochalasins have the ability to bind to actin filaments and block polymerization and elongation of actin. As a result, they can change cellular morphology, inhibit cellular processes and cause cells to undergo apoptosis (1). Cytochalasin D in particular can inhibit protein synthesis (2).
References 1.  Haidle A., and Myers A. (2004) Proc Natl Acad Sci. 101(33): 12048-12053.
2. Ornelles et al., (1986) Mol Cell Biol. 6(5): 1650-1662.

Cyclosporine

Cyclosporine__Immunosuppressant CUDC-907

Product Name Cyclosporine
Description

Immunosuppressant
Purity >99%
CAS No. 59865-13-3
Molecular Formula C62H111N11O12
Molecular Weight 1202.63
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO, 50 mM in ethanol
Source Synthetic
Appearance White Solid
SMILES CCemail protected1C(=O)N(CC(=O)N(email protected(C(=O)Nemail protected(C(=O)N(email protected(C(=O)Nemail protected(C(=O)NC@@H(C(=O)N(email protected(C(=O)N(email protected(C(=O)N(email protected(C(=O)N(email protected(C(=O)N1)C@@H(email protected(C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(
InChI InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(
InChIKey PMATZTZNYRCHOR-IMVLJIQESA-N
Safety Phrases Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R20/21/22 – Harmful by inhilation, in contact with skin and if swallowed
R45 – May cause cancer
R62 – Possible risk of impaired fertility
R68 – Possible risk of irreversible effects
Hazard Phrases:
H302-H350-H360
Precautionary Phrases:
P201-P308 + P313
Cite This Product Cyclosporine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-201)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120072

Alternative Names (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,3 1-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, Cyclosporin A
Research Areas Cancer, Apoptosis
PubChem ID 5284373
Scientific Background Cyclosporin A is a hydrophobic cyclic peptide, and is a potent immune-suppressant and antifungal. It acts via its ability to bind to a family of intracellular proteins (1). The immunosuppressant action is mediated by the complex Cyclosporin-A-cyclophilin that specifically inhibits the Ca2+/calmodulin-dependent serine-threonine-protein phosphatase-2B. This is turn inhibits calcineurin and promotes dephosphorylation of transcription factor NF-AT and T-cell activation (2).
References 1. Heitman J., et al. (1992) New Biol. 4:448.
2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.

Cyclopamine

Cyclopamine__Hedgehog signaling blocker Vanoxerine

Product Name Cyclopamine
Description

Hedgehog signaling blocker
Purity >98%
CAS No. 4449-51-8
Molecular Formula C27H41NO2
Molecular Weight 434.15
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 5 mM in ethanol
Source Synthetic
Appearance White Solid
SMILES Cemail protected1CC@@H2email protected(email protected(C@3(O2)CCemail protected4C@@H5CC=C6Cemail protected(CCC@@6(email protected5CC4=C3C)C)O)C)NC1
InChI InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17
InChIKey QASFUMOKHFSJGL-LAFRSMQTSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62- Possible risk of impaired fertility
Cite This Product Cyclopamine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-226)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120058

Alternative Names (3β,22S,23R)-17,23-Epoxyveratraman-3-ol
Research Areas Cancer, Apoptosis, Cancer Growth Inhibitors, Hedgehog Pathway Blocker
PubChem ID 442972
Scientific Background Cyclopamine is a hedgehog signaling pathway inhibitor that influences the balance between the active and inactive forms of the Smoothened protein (1). It is being investigated as a treatment agent in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma (1, 2).
References 1. Beachy P.A., et al. (2000) Nature. 406(6799): 1005-1009.
2. Yauch R.L., et al. (2009) Science. 326(5952): 572-574.