Anti-DUSP11 Antibody__Rabbit Anti-Human DUSP11 Polyclonal AMG 487
Anti-DUSP11 Antibody
Anti-DUSP11 Antibody__Rabbit Anti-Human DUSP11 Polyclonal Birinapant
Storage Buffer
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature
-20ºC
Shipping Temperature
Blue Ice or 4ºC
Purification
Peptide Affinity Purified
Clonality
Polyclonal
Specificity
Detects ~38kDa.
Cite This Product
Rabbit Anti-Human DUSP11 Polyclonal (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPC-1118)
Certificate of Analysis
A 1:250 dilution of SPC-1118 was sufficient for detection of DUSP11 in 10 µg of human kidney lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19121696
Alternative Names
Dual specificity phosphatase 11 antibody, Dual specificity protein phosphatase 11 antibody, DUS11_HUMAN antibody, DUSP11 antibody, Phosphatase that interacts with RNA/RNP complex 1 antibody, PIR1 antibody, RNA/RNP complex 1 interacting antibody, RNA/RNP complex interacting phosphatase antibody
Cellular Localization
Nucleus
Accession Number
NP_003575
Gene ID
8446
Swiss Prot
O75319
Scientific Background
DUSP11 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.
Duloxetine HCl
Duloxetine HCl__5-HT-noradrenaline reuptake inhibitor THZ1-R
Product Name
Duloxetine HCl
Description
5-HT-noradrenaline reuptake inhibitor
Purity
>98% (TLC); NMR (Conforms)
CAS No.
136434-34-9
Molecular Formula
C18H19NOS.HCl
Molecular Weight
333.9
Storage Temperature
-20ºC
Shipping Temperature
Blue Ice or 4ºC
Product Type
Inhibitor
Solubility
May be dissolved in DMSO (30 mg/ml); or water (3 mg/ml)
Source
Synthetic
Appearance
White powder
SMILES
CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl
InChI
InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
InChIKey
BFFSMCNJSOPUAY-LMOVPXPDSA-N
Safety Phrases
WHMIS Classification:
Not WHMIS controlled.
GHS Classification:
Acute toxicity, Oral (Category 4)
Signal word: Warning
Hazard statement(s):
H302 Harmful if swallowed.
Precautionary statement(s) none
HMIS Classification:
Health hazard: 1
Flammability: 0
Physical hazards: 0
Potential Health Effects:
Inhalation – May be harmful if inhaled. May cause respiratory tract irritation.
Skin – Harmful if absorbed through skin. May cause skin irritation.
Eyes – May cause eye irritation.
Ingestion – Harmful if swallowed.
Cite This Product
Duloxetine HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-549)
References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19121687
Alternative Names
Duloxetine Hydrochloride, (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride, (S)-Duloxetine hydrochloride, (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride, (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride, (+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride, (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine;hydrochloride, Duloxetine HCl
Research Areas
Alpha-2 Adrenergic Receptors, Neuroscience, Neurotransmitter Receptors
PubChem ID
60834
5-HT-noradrenaline reuptake inhibitor
Not WHMIS controlled.
GHS Classification:
Acute toxicity, Oral (Category 4)
Signal word: Warning
Hazard statement(s):
H302 Harmful if swallowed.
Precautionary statement(s) none
HMIS Classification:
Health hazard: 1
Flammability: 0
Physical hazards: 0
Potential Health Effects:
Inhalation – May be harmful if inhaled. May cause respiratory tract irritation.
Skin – Harmful if absorbed through skin. May cause skin irritation.
Eyes – May cause eye irritation.
Ingestion – Harmful if swallowed.
Doxorubicin Hydrochloride
Doxorubicin Hydrochloride__Autophagy inducer GSK2330672
Product Name
Doxorubicin Hydrochloride
Description
Autophagy inducer
Purity
>98% (TLC); NMR (Conforms)
CAS No.
25316-40-9
Molecular Formula
C27H29NO11•HCl
Molecular Weight
580
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble in water (50 mM).
Source
Synthetic
Appearance
Red solid
SMILES
email protected2(OC1OC(C(O)C(N)C1)C)CC@@(O)(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)C(=O)CO.H+.Cl-
InChI
InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3
InChIKey
MWWSFMDVAYGXBV-RUELKSSGSA-N
Safety Phrases
Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H350- May cause cancer.
Precautionary statements:
P201- Obtain special instructions before use.
P308 + P313- IF exposed or concerned: Get medical advice/ attention.
Cite This Product
Doxorubicin Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-390)
References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19121623
Alternative Names
Adriamycin
Research Areas
Cancer, Autophagy
PubChem ID
443939
Scientific Background
Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefore induces apoptosis by hindering cellular functions like replication and transcription by specifically inhibiting the binding of reverse transcriptase, RNA polymerase and topoisomerase II. Doxorubicin has some adverse effects for patients including immunosuppressive effects caused by hematologic toxicity. Doxorubicin has also been shown to induce autophagy in a species-specific manner.
References
1. Kusayanagi, T. et al. (2012). Bioorg Med Chem. 20(21): 6248-55.
2. Chen, N. T. et al. (2012). PLoS One. 7(9).
3. Patel, S. et al. (1997). Mol Pharmacol. 52(4): 658-66.
4. Cutts, S. et al. (1996). J Biol Chem. 271(10): 5422-9.
5. Danesi, R. et al. (2004). Transplant Proc. 36(3): 703-4.
6. Dirks-Naylor, A. (2013). Life Sci. 93(24): 913-6.
Autophagy inducer
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H350- May cause cancer.
Precautionary statements:
P201- Obtain special instructions before use.
P308 + P313- IF exposed or concerned: Get medical advice/ attention.
2. Chen, N. T. et al. (2012). PLoS One. 7(9).
3. Patel, S. et al. (1997). Mol Pharmacol. 52(4): 658-66.
4. Cutts, S. et al. (1996). J Biol Chem. 271(10): 5422-9.
5. Danesi, R. et al. (2004). Transplant Proc. 36(3): 703-4.
6. Dirks-Naylor, A. (2013). Life Sci. 93(24): 913-6.
Dovitinib
Dovitinib__FGFR3 inhibitor A939572
Product Name
Dovitinib
Description
FGFR3 inhibitor
Purity
>98%
CAS No.
405169-16-6
Molecular Formula
C21H21FN6O
Molecular Weight
392.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO
Source
Synthetic
Appearance
Crystalline solid
SMILES
CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N
InChI
InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11,24-25H,7-10,23H2,1H3/b20-18-
InChIKey
KCOYQXZDFIIGCY-ZZEZOPTASA-N
Safety Phrases
Classification:
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 2
Target Organ Systemic Toxicity (single exposure), Category 3
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary statements:
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P332+313: If skin irritation occurs, get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists, get medical advice/attention.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312: Call a {POISON CENTER/doctor/…} if you feel unwell.
Cite This Product
Dovitinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-500)
References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19121595
Alternative Names
4-amino-5-fluoro-3-6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl-2(1H)-quinolinone
Research Areas
Cell Signaling
PubChem ID
9886808
Scientific Background
Dovitinib is a potent growth factor receptor kinase inhibitor with effects against FLT-3, c-KIT, VEGFR, PDGFRß and CSF-1R.
References
1. Konecny G.E., et al. (2013) Mol. Cancer Ther. 12(5): 632–642.
FGFR3 inhibitor
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 2
Target Organ Systemic Toxicity (single exposure), Category 3
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary statements:
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P332+313: If skin irritation occurs, get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists, get medical advice/attention.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312: Call a {POISON CENTER/doctor/…} if you feel unwell.
Anti-Doublecortin Antibody
Anti-Doublecortin Antibody__Rabbit Anti-Human Doublecortin Polyclonal c-Kit-IN-1
Product Name
Doublecortin Antibody
Description
Rabbit Anti-Human Doublecortin Polyclonal
Species Reactivity
Human, Mouse, Rat
Applications
,
WB
,
ELISA
Antibody Dilution
WB (1:1000), ELISA (1:10000); optimal dilutions for assays should be determined by the user.
Host Species
Rabbit
Immunogen Species
Human
Immunogen
Synthesized unphosphorylated peptide derived from human Doublecortin around the phosphorylation site of serine 376 (P-T-SP-P-G).
Conjugates
Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated
APC (Allophycocyanin)
Overview:
- High quantum yield
- Large phycobiliprotein
- 6 chromophores per molecule
- Isolated from red algae
- Molecular Weight: 105 kDa

Optical Properties:
λex = 650 nm
λem = 660 nm
εmax = 7.0×105
Φf = 0.68
Brightness = 476
Laser = 594 or 633 nm
Filter set = Cy®5
ATTO 390
Overview:
- High fluorescence yield
- Large Stokes-shift (89 nm)
- Good photostability
- Moderately hydrophilic
- Good solubility in polar solvents
- Coumarin derivate, uncharged
- Low molar mass: 343.42 g/mol
ATTO 390 Datasheet

Optical Properties:
λex = 390 nm
λem = 479 nm
εmax = 2.4×104
Φf = 0.90
τfl = 5.0 ns
Brightness = 21.6
Laser = 365 or 405 nm
ATTO 488
Overview:

Optical Properties:
λex = 501 nm
λem = 523 nm
εmax = 9.0×104
Φf = 0.80
τfl = 4.1 ns
Brightness = 72
Laser = 488 nm
Filter set = FITC
ATTO 565
Overview:

Optical Properties:
λex = 563 nm
λem = 592 nm
εmax = 1.2×105
Φf = 0.9
τfl = 3.4 n
Brightness = 10
Laser = 532 nm
Filter set = TRITC
ATTO 594
Overview:

Optical Properties:
λex = 601 nm
λem = 627 nm
εmax = 1.2×105
Φf = 0.85
τfl = 3.5 ns
Brightness = 102
Laser = 594 nm
Filter set = Texas Red®
ATTO 633
Overview:

Optical Properties:
λex = 629 nm
λem = 657 nm
εmax = 1.3×105
Φf = 0.64
τfl = 3.2 ns
Brightness = 83.2
Laser = 633 nm
Filter set = Cy®5
ATTO 655
Overview:

Optical Properties:
λex = 663 nm
λem = 684 nm
εmax = 1.25×105
Φf = 0.30
τfl = 1.8 ns
Brightness = 37.5
Laser = 633 – 647 nm
Filter set = Cy®5
ATTO 680
Overview:

Optical Properties:
λex = 680 nm
λem = 700 nm
εmax = 1.25×105
Φf = 0.30
τfl = 1.7 ns
Brightness = 37.5
Laser = 633 – 676 nm
Filter set = Cy®5.5
ATTO 700
Overview:
- High fluorescence yield
- Excellent thermal and photostability
- Quenched by electron donors
- Very hydrophilic
- Good solubility in polar solvents
- Zwitterionic dye
- Molar Mass: 575 g/mol

Optical Properties:
λex = 700 nm
λem = 719 nm
εmax = 1.25×105
Φf = 0.25
τfl = 1.6 ns
Brightness = 31.3
Laser = 676 nm
Filter set = Cy®5.5
FITC (Fluorescein)
Overview:

Optical Properties:
λex = 494 nm
λem = 520 nm
εmax = 7.3×104
Φf = 0.92
τfl = 5.0 ns
Brightness = 67.2
Laser = 488 nm
Filter set = FITC
PE/ATTO 594
PE/ATTO 594 is a tandem conjugate, where PE is excited at 535 nm and transfers energy to ATTO 594 via FRET (fluorescence resonance energy transfer), which emits at 627 nm.
Overview:

Optical Properties:
λex = 535 nm
λem = 627 nm
Laser = 488 to 561 nm
PerCP
Overview:

Optical Properties:
λex = 482 nm
λem = 677 nm
εmax = 1.96 x 106
Laser = 488 nm
R-PE (R-Phycoerythrin)
Overview:

Optical Properties:
λex = 565 nm
λem = 575 nm
εmax = 2.0×106
Φf = 0.84
Brightness = 1.68 x 103
Laser = 488 to 561 nm
Filter set = TRITC
AP (Alkaline Phosphatase)
Properties:
- Broad enzymatic activity for phosphate esters of alcohols, amines, pyrophosphate, and phenols
- Commonly used to dephosphorylate the 5’-termini of DNA and RNA to prevent self-ligation
- Catalyzes the conversion of:
- Chromogenic substrates (e.g. pNPP, naphthol AS-TR phosphate, BCIP) into coloured products
- Fluorogenic substrates (e.g. 4-methylumbelliferyl phosphate) into fluorescent products
- Molecular weight: 140 kDa
- Applications: Western blot, immunohistochemistry, and ELISA
HRP (Horseradish peroxidase)
Properties:
- Enzymatic activity is used to amplify weak signals and increase visibility of a target
- Readily combines with hydrogen peroxide (H2O2) to form HRP-H2O2 complex which can oxidize various hydrogen donors
- Catalyzes the conversion of:
- Chromogenic substrates (e.g. TMB, DAB, ABTS) into coloured products
- Chemiluminescent substrates (e.g. luminol and isoluminol) into light emitting products via enhanced chemiluminescence (ECL)
- Fluorogenic substrates (e.g. tyramine, homovanillic acid, and 4-hydroxyphenyl acetic acid) into fluorescent products
- High turnover rate enables rapid generation of a strong signal
- 44 kDa glycoprotein
- Extinction coefficient: 100 (403 nm)
- Applications: Western blot, immunohistochemistry, and ELISA
Biotin
Properties:
Streptavidin
Properties:
- Homo-tetrameric protein purified from Streptomyces avidinii which binds four biotin molecules with extremely high affinity
- Molecular weight: 53 kDa
- Formula: C10H16N2O3S
- Applications: Western blot, immunohistochemistry, and ELISA
Storage Buffer
PBS (without Mg2+ and Ca2+), pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Storage Temperature
-20ºC
Shipping Temperature
Blue Ice or 4ºC
Purification
Affinity Purified
Clonality
Polyclonal
Isotype
IgG
Specificity
Detects ~45kDa, endogenous levels of total Doublecortin protein.
Cite This Product
Rabbit Anti-Human Doublecortin Polyclonal (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPC-1294)
Certificate of Analysis
A 1:1000 dilution of SPC-1294 was sufficient for detection of Doublecortin in 10 µg of Jurkat cell lysates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19121538
Alternative Names
DBCN Antibody, Dbct Antibody, DC Antibody, DCX Antibody, DCX_HUMAN Antibody, Doublecortex Antibody, Doublin Antibody, FLJ51296 Antibody, Lis X Antibody, Lis-X Antibody, Lissencephalin X Antibody, Lissencephalin-X Antibody, Lissencephaly X linked Antibody, Lissencephaly X linked doublecortin Antibody, LISX Antibody, Neuronal migration protein doublecortin Antibody, OTTHUMP00000023859 Antibody, OTTHUMP00000023860 Antibody, OTTHUMP00000216315 Antibody, OTTHUMP00000216316 Antibody, SCLH Antibody, XLIS Antibody
Research Areas
Cell Structure, Neuroscience
Cellular Localization
Cytoplasm, Cell projection, Cytoskeleton, Cytosol
Accession Number
NP_000546.2
Gene ID
1641
Swiss Prot
O43602
Scientific Background
Neuronal migration protein doublecortin is a protein that in humans is encoded by the DCX gene, also known as doublin or lissencephalin-X. Doublecortin (DCX) is a microtubule-associated protein expressed almost exclusively in immature neurons. Neuronal precursors begin to express DCX shortly after exiting the cell cycle, and continue to express DCX for 2-3 weeks as the cells mature into neurons. It seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway.
References
1. Oomen C.A. et al. (2009) PLoS ONE 4 (1): e3675.
2. Brown J.P. et al. (2003) J. Comp. Neurol. 467 (1): 1–10.
3. Couillard-Despres S. et al. (2005) Eur. J. Neurosci. 21 (1): 1–14.
Rabbit Anti-Human Doublecortin Polyclonal
WB
,
ELISA
APC (Allophycocyanin) | ||
Overview:
|
![]() |
Optical Properties:
λex = 650 nm λem = 660 nm εmax = 7.0×105 Φf = 0.68 Brightness = 476 Laser = 594 or 633 nm Filter set = Cy®5 |
ATTO 390 | ||
Overview:
ATTO 390 Datasheet |
![]() |
Optical Properties:
λex = 390 nm λem = 479 nm εmax = 2.4×104 Φf = 0.90 τfl = 5.0 ns Brightness = 21.6 Laser = 365 or 405 nm |
ATTO 488 | ||
Overview: | ![]() |
Optical Properties:
λex = 501 nm λem = 523 nm εmax = 9.0×104 Φf = 0.80 τfl = 4.1 ns Brightness = 72 Laser = 488 nm Filter set = FITC |
ATTO 565 | ||
Overview: | ![]() |
Optical Properties:
λex = 563 nm λem = 592 nm εmax = 1.2×105 Φf = 0.9 τfl = 3.4 n Brightness = 10 Laser = 532 nm Filter set = TRITC |
ATTO 594 | ||
Overview: | ![]() |
Optical Properties:
λex = 601 nm λem = 627 nm εmax = 1.2×105 Φf = 0.85 τfl = 3.5 ns Brightness = 102 Laser = 594 nm Filter set = Texas Red® |
ATTO 633 | ||
Overview: | ![]() |
Optical Properties:
λex = 629 nm λem = 657 nm εmax = 1.3×105 Φf = 0.64 τfl = 3.2 ns Brightness = 83.2 Laser = 633 nm Filter set = Cy®5 |
ATTO 655 | ||
Overview: | ![]() |
Optical Properties:
λex = 663 nm λem = 684 nm εmax = 1.25×105 Φf = 0.30 τfl = 1.8 ns Brightness = 37.5 Laser = 633 – 647 nm Filter set = Cy®5 |
ATTO 680 | ||
Overview: | ![]() |
Optical Properties:
λex = 680 nm λem = 700 nm εmax = 1.25×105 Φf = 0.30 τfl = 1.7 ns Brightness = 37.5 Laser = 633 – 676 nm Filter set = Cy®5.5 |
ATTO 700 | ||
Overview:
|
![]() |
Optical Properties:
λex = 700 nm λem = 719 nm εmax = 1.25×105 Φf = 0.25 τfl = 1.6 ns Brightness = 31.3 Laser = 676 nm Filter set = Cy®5.5 |
FITC (Fluorescein) | ||
Overview: | ![]() |
Optical Properties:
λex = 494 nm λem = 520 nm εmax = 7.3×104 Φf = 0.92 τfl = 5.0 ns Brightness = 67.2 Laser = 488 nm Filter set = FITC |
PE/ATTO 594 | ||
PE/ATTO 594 is a tandem conjugate, where PE is excited at 535 nm and transfers energy to ATTO 594 via FRET (fluorescence resonance energy transfer), which emits at 627 nm. | ||
Overview: | ![]() |
Optical Properties:
λex = 535 nm λem = 627 nm Laser = 488 to 561 nm |
PerCP | ||
Overview: | ![]() |
Optical Properties:
λex = 482 nm λem = 677 nm εmax = 1.96 x 106 Laser = 488 nm |
R-PE (R-Phycoerythrin) | ||
Overview: | ![]() |
Optical Properties:
λex = 565 nm λem = 575 nm εmax = 2.0×106 Φf = 0.84 Brightness = 1.68 x 103 Laser = 488 to 561 nm Filter set = TRITC |
AP (Alkaline Phosphatase)
Properties:
- Broad enzymatic activity for phosphate esters of alcohols, amines, pyrophosphate, and phenols
- Commonly used to dephosphorylate the 5’-termini of DNA and RNA to prevent self-ligation
- Catalyzes the conversion of:
- Chromogenic substrates (e.g. pNPP, naphthol AS-TR phosphate, BCIP) into coloured products
- Fluorogenic substrates (e.g. 4-methylumbelliferyl phosphate) into fluorescent products
- Molecular weight: 140 kDa
- Applications: Western blot, immunohistochemistry, and ELISA
HRP (Horseradish peroxidase)
Properties:
- Enzymatic activity is used to amplify weak signals and increase visibility of a target
- Readily combines with hydrogen peroxide (H2O2) to form HRP-H2O2 complex which can oxidize various hydrogen donors
- Catalyzes the conversion of:
- Chromogenic substrates (e.g. TMB, DAB, ABTS) into coloured products
- Chemiluminescent substrates (e.g. luminol and isoluminol) into light emitting products via enhanced chemiluminescence (ECL)
- Fluorogenic substrates (e.g. tyramine, homovanillic acid, and 4-hydroxyphenyl acetic acid) into fluorescent products
- High turnover rate enables rapid generation of a strong signal
- 44 kDa glycoprotein
- Extinction coefficient: 100 (403 nm)
- Applications: Western blot, immunohistochemistry, and ELISA
Biotin
Properties:
Streptavidin
Properties:
- Homo-tetrameric protein purified from Streptomyces avidinii which binds four biotin molecules with extremely high affinity
- Molecular weight: 53 kDa
- Formula: C10H16N2O3S
- Applications: Western blot, immunohistochemistry, and ELISA
2. Brown J.P. et al. (2003) J. Comp. Neurol. 467 (1): 1–10.
3. Couillard-Despres S. et al. (2005) Eur. J. Neurosci. 21 (1): 1–14.
Dorsomorphin
Dorsomorphin__AMPK kinase inhibitor TRV130 (hydrochloride)
Product Name
Dorsomorphin
Description
AMPK kinase inhibitor
Purity
>98% (HPLC)
CAS No.
866405-64-3
Molecular Formula
C24H25N5O
Molecular Weight
399.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (4 mg/ml, warm)
Source
Synthetic
Appearance
Yellow solid
SMILES
C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3
InChI
InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
InChIKey
XHBVYDAKJHETMP-UHFFFAOYSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 4), H332
Acute toxicity, Dermal (Category 4), H312
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well – ventilated area.
P280 Wear protective gloves/ protective clothing.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Cite This Product
Dorsomorphin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-443)
References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19121497
Alternative Names
AMPK Inhibitor, Compound C, 6-4-(2-Piperidin-1-ylethoxy)phenyl-3-pyridin-4-ylpyrazolo1,5-apyrimidine
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
11524144
Scientific Background
Dorsomorphin is a potent and selective and reversible inhibitor of AMP-kinase, doing so in an ATP-competitive manner. It is also a selective inhibitor of Bone morphogenetic protein (BMP) signaling.
References
1. Vucicevic L., et al. (2011) Autophagy 7(1): 40–50.
2. Yu P.B., et al. (2008). Nat. Chem. Biol. 4(1): 33–41.
AMPK kinase inhibitor
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 4), H332
Acute toxicity, Dermal (Category 4), H312
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well – ventilated area.
P280 Wear protective gloves/ protective clothing.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
2. Yu P.B., et al. (2008). Nat. Chem. Biol. 4(1): 33–41.
Doramapimod
Doramapimod__p38 MAP kinase inhibitor Kaempferol
Product Name
Doramapimod
Description
p38 MAP kinase inhibitor
Purity
>99% (HPLC)
CAS No.
285983-48-4
Molecular Formula
C31H37N5O3
Molecular Weight
527.7
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO
Source
Synthetic
Appearance
White solid
SMILES
C2=CC(=C1C=CC=CC1=C2NC(NC3=CC(=NN3C4=CC=C(C=C4)C)C(C)(C)C)=O)OCCN5CCOCC5
InChI
InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
InChIKey
MVCOAUNKQVWQHZ-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Doramapimod (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-442)
References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19121476
Alternative Names
JNK Inhibitor XVII, BIRB796, 1-5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl-3-4-(2-morpholin-4-ylethoxy)naphthalen-1-ylurea
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
156422
Scientific Background
Doramapimod is a highly potent and selective inhibitor of p38α MAPK. It specifically blocks TNFα release.
References
1. Pargellis C., et al. (2002). Nat Structural Biol. 9(4): 268–272.
p38 MAP kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Anti-DOK3 Antibody (pTyr398)
Anti-DOK3 Antibody (pTyr398)__Rabbit Anti-Human DOK3 (pTyr398) Polyclonal Tenofovir (Disoproxil Fumarate)
Product Name
DOK3 Antibody (pTyr398)
Description
Rabbit Anti-Human DOK3 (pTyr398) Polyclonal
Species Reactivity
Human
Applications
,
WB
,
AM
Antibody Dilution
WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species
Rabbit
Immunogen Species
Human
Immunogen
A phospho-specific peptide corresponding to residues surrounding Tyr397 of human EML4 (AA395-401)
Conjugates
Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated
APC (Allophycocyanin)
Overview:
- High quantum yield
- Large phycobiliprotein
- 6 chromophores per molecule
- Isolated from red algae
- Molecular Weight: 105 kDa

Optical Properties:
λex = 650 nm
λem = 660 nm
εmax = 7.0×105
Φf = 0.68
Brightness = 476
Laser = 594 or 633 nm
Filter set = Cy®5
ATTO 390
Overview:
- High fluorescence yield
- Large Stokes-shift (89 nm)
- Good photostability
- Moderately hydrophilic
- Good solubility in polar solvents
- Coumarin derivate, uncharged
- Low molar mass: 343.42 g/mol
ATTO 390 Datasheet

Optical Properties:
λex = 390 nm
λem = 479 nm
εmax = 2.4×104
Φf = 0.90
τfl = 5.0 ns
Brightness = 21.6
Laser = 365 or 405 nm
ATTO 488
Overview:

Optical Properties:
λex = 501 nm
λem = 523 nm
εmax = 9.0×104
Φf = 0.80
τfl = 4.1 ns
Brightness = 72
Laser = 488 nm
Filter set = FITC
ATTO 565
Overview:

Optical Properties:
λex = 563 nm
λem = 592 nm
εmax = 1.2×105
Φf = 0.9
τfl = 3.4 n
Brightness = 10
Laser = 532 nm
Filter set = TRITC
ATTO 594
Overview:

Optical Properties:
λex = 601 nm
λem = 627 nm
εmax = 1.2×105
Φf = 0.85
τfl = 3.5 ns
Brightness = 102
Laser = 594 nm
Filter set = Texas Red®
ATTO 633
Overview:

Optical Properties:
λex = 629 nm
λem = 657 nm
εmax = 1.3×105
Φf = 0.64
τfl = 3.2 ns
Brightness = 83.2
Laser = 633 nm
Filter set = Cy®5
ATTO 655
Overview:

Optical Properties:
λex = 663 nm
λem = 684 nm
εmax = 1.25×105
Φf = 0.30
τfl = 1.8 ns
Brightness = 37.5
Laser = 633 – 647 nm
Filter set = Cy®5
ATTO 680
Overview:

Optical Properties:
λex = 680 nm
λem = 700 nm
εmax = 1.25×105
Φf = 0.30
τfl = 1.7 ns
Brightness = 37.5
Laser = 633 – 676 nm
Filter set = Cy®5.5
ATTO 700
Overview:
- High fluorescence yield
- Excellent thermal and photostability
- Quenched by electron donors
- Very hydrophilic
- Good solubility in polar solvents
- Zwitterionic dye
- Molar Mass: 575 g/mol

Optical Properties:
λex = 700 nm
λem = 719 nm
εmax = 1.25×105
Φf = 0.25
τfl = 1.6 ns
Brightness = 31.3
Laser = 676 nm
Filter set = Cy®5.5
FITC (Fluorescein)
Overview:

Optical Properties:
λex = 494 nm
λem = 520 nm
εmax = 7.3×104
Φf = 0.92
τfl = 5.0 ns
Brightness = 67.2
Laser = 488 nm
Filter set = FITC
PE/ATTO 594
PE/ATTO 594 is a tandem conjugate, where PE is excited at 535 nm and transfers energy to ATTO 594 via FRET (fluorescence resonance energy transfer), which emits at 627 nm.
Overview:

Optical Properties:
λex = 535 nm
λem = 627 nm
Laser = 488 to 561 nm
PerCP
Overview:

Optical Properties:
λex = 482 nm
λem = 677 nm
εmax = 1.96 x 106
Laser = 488 nm
R-PE (R-Phycoerythrin)
Overview:

Optical Properties:
λex = 565 nm
λem = 575 nm
εmax = 2.0×106
Φf = 0.84
Brightness = 1.68 x 103
Laser = 488 to 561 nm
Filter set = TRITC
AP (Alkaline Phosphatase)
Properties:
- Broad enzymatic activity for phosphate esters of alcohols, amines, pyrophosphate, and phenols
- Commonly used to dephosphorylate the 5’-termini of DNA and RNA to prevent self-ligation
- Catalyzes the conversion of:
- Chromogenic substrates (e.g. pNPP, naphthol AS-TR phosphate, BCIP) into coloured products
- Fluorogenic substrates (e.g. 4-methylumbelliferyl phosphate) into fluorescent products
- Molecular weight: 140 kDa
- Applications: Western blot, immunohistochemistry, and ELISA
HRP (Horseradish peroxidase)
Properties:
- Enzymatic activity is used to amplify weak signals and increase visibility of a target
- Readily combines with hydrogen peroxide (H2O2) to form HRP-H2O2 complex which can oxidize various hydrogen donors
- Catalyzes the conversion of:
- Chromogenic substrates (e.g. TMB, DAB, ABTS) into coloured products
- Chemiluminescent substrates (e.g. luminol and isoluminol) into light emitting products via enhanced chemiluminescence (ECL)
- Fluorogenic substrates (e.g. tyramine, homovanillic acid, and 4-hydroxyphenyl acetic acid) into fluorescent products
- High turnover rate enables rapid generation of a strong signal
- 44 kDa glycoprotein
- Extinction coefficient: 100 (403 nm)
- Applications: Western blot, immunohistochemistry, and ELISA
Biotin
Properties:
Streptavidin
Properties:
- Homo-tetrameric protein purified from Streptomyces avidinii which binds four biotin molecules with extremely high affinity
- Molecular weight: 53 kDa
- Formula: C10H16N2O3S
- Applications: Western blot, immunohistochemistry, and ELISA
Storage Buffer
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature
-20ºC
Shipping Temperature
Blue Ice or 4ºC
Purification
Peptide Affinity Purified
Clonality
Polyclonal
Specificity
Detects 53.288 kDa.
Cite This Product
Rabbit Anti-Human DOK3 (pTyr398) Polyclonal (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPC-958)
Certificate of Analysis
A 1:250 dilution of SPC-958 was sufficient for detection of DOK3 (pTyr398) in 10 µg of HepG2 cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19121464
Alternative Names
Docking protein 3 Antibody, DOK Like Protein Antibody, Dok3 Antibody, DOKL Pending Antibody, Downstream of tyrosine kinase 3 Antibody, p62 DOK Like Protein Antibody
Cellular Localization
Cytoplasm, Cell membrane
Accession Number
NP_001138347
Gene ID
79930
Swiss Prot
Q7L591
Scientific Background
DOK3 is a member of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. DOK3 is an adapter involved in the recruitment of inhibitory molecules and is highly expressed in B cells and macrophages. Immunoreceptor-mediated cellular activation induces tyrosine phosphorylation of DOK3. Upon phosphorylation, DOK3 binds to 5’ inositol phosphatase SHIP and the protein tyrosine kinase Csk. DOK3 may play a significant role in the negative regulation of immunoreceptor signaling in hemopoietic cells.
Rabbit Anti-Human DOK3 (pTyr398) Polyclonal
WB
,
AM
APC (Allophycocyanin) | ||
Overview:
|
![]() |
Optical Properties:
λex = 650 nm λem = 660 nm εmax = 7.0×105 Φf = 0.68 Brightness = 476 Laser = 594 or 633 nm Filter set = Cy®5 |
ATTO 390 | ||
Overview:
ATTO 390 Datasheet |
![]() |
Optical Properties:
λex = 390 nm λem = 479 nm εmax = 2.4×104 Φf = 0.90 τfl = 5.0 ns Brightness = 21.6 Laser = 365 or 405 nm |
ATTO 488 | ||
Overview: | ![]() |
Optical Properties:
λex = 501 nm λem = 523 nm εmax = 9.0×104 Φf = 0.80 τfl = 4.1 ns Brightness = 72 Laser = 488 nm Filter set = FITC |
ATTO 565 | ||
Overview: | ![]() |
Optical Properties:
λex = 563 nm λem = 592 nm εmax = 1.2×105 Φf = 0.9 τfl = 3.4 n Brightness = 10 Laser = 532 nm Filter set = TRITC |
ATTO 594 | ||
Overview: | ![]() |
Optical Properties:
λex = 601 nm λem = 627 nm εmax = 1.2×105 Φf = 0.85 τfl = 3.5 ns Brightness = 102 Laser = 594 nm Filter set = Texas Red® |
ATTO 633 | ||
Overview: | ![]() |
Optical Properties:
λex = 629 nm λem = 657 nm εmax = 1.3×105 Φf = 0.64 τfl = 3.2 ns Brightness = 83.2 Laser = 633 nm Filter set = Cy®5 |
ATTO 655 | ||
Overview: | ![]() |
Optical Properties:
λex = 663 nm λem = 684 nm εmax = 1.25×105 Φf = 0.30 τfl = 1.8 ns Brightness = 37.5 Laser = 633 – 647 nm Filter set = Cy®5 |
ATTO 680 | ||
Overview: | ![]() |
Optical Properties:
λex = 680 nm λem = 700 nm εmax = 1.25×105 Φf = 0.30 τfl = 1.7 ns Brightness = 37.5 Laser = 633 – 676 nm Filter set = Cy®5.5 |
ATTO 700 | ||
Overview:
|
![]() |
Optical Properties:
λex = 700 nm λem = 719 nm εmax = 1.25×105 Φf = 0.25 τfl = 1.6 ns Brightness = 31.3 Laser = 676 nm Filter set = Cy®5.5 |
FITC (Fluorescein) | ||
Overview: | ![]() |
Optical Properties:
λex = 494 nm λem = 520 nm εmax = 7.3×104 Φf = 0.92 τfl = 5.0 ns Brightness = 67.2 Laser = 488 nm Filter set = FITC |
PE/ATTO 594 | ||
PE/ATTO 594 is a tandem conjugate, where PE is excited at 535 nm and transfers energy to ATTO 594 via FRET (fluorescence resonance energy transfer), which emits at 627 nm. | ||
Overview: | ![]() |
Optical Properties:
λex = 535 nm λem = 627 nm Laser = 488 to 561 nm |
PerCP | ||
Overview: | ![]() |
Optical Properties:
λex = 482 nm λem = 677 nm εmax = 1.96 x 106 Laser = 488 nm |
R-PE (R-Phycoerythrin) | ||
Overview: | ![]() |
Optical Properties:
λex = 565 nm λem = 575 nm εmax = 2.0×106 Φf = 0.84 Brightness = 1.68 x 103 Laser = 488 to 561 nm Filter set = TRITC |
AP (Alkaline Phosphatase)
Properties:
- Broad enzymatic activity for phosphate esters of alcohols, amines, pyrophosphate, and phenols
- Commonly used to dephosphorylate the 5’-termini of DNA and RNA to prevent self-ligation
- Catalyzes the conversion of:
- Chromogenic substrates (e.g. pNPP, naphthol AS-TR phosphate, BCIP) into coloured products
- Fluorogenic substrates (e.g. 4-methylumbelliferyl phosphate) into fluorescent products
- Molecular weight: 140 kDa
- Applications: Western blot, immunohistochemistry, and ELISA
HRP (Horseradish peroxidase)
Properties:
- Enzymatic activity is used to amplify weak signals and increase visibility of a target
- Readily combines with hydrogen peroxide (H2O2) to form HRP-H2O2 complex which can oxidize various hydrogen donors
- Catalyzes the conversion of:
- Chromogenic substrates (e.g. TMB, DAB, ABTS) into coloured products
- Chemiluminescent substrates (e.g. luminol and isoluminol) into light emitting products via enhanced chemiluminescence (ECL)
- Fluorogenic substrates (e.g. tyramine, homovanillic acid, and 4-hydroxyphenyl acetic acid) into fluorescent products
- High turnover rate enables rapid generation of a strong signal
- 44 kDa glycoprotein
- Extinction coefficient: 100 (403 nm)
- Applications: Western blot, immunohistochemistry, and ELISA
Biotin
Properties:
Streptavidin
Properties:
- Homo-tetrameric protein purified from Streptomyces avidinii which binds four biotin molecules with extremely high affinity
- Molecular weight: 53 kDa
- Formula: C10H16N2O3S
- Applications: Western blot, immunohistochemistry, and ELISA
Dofetilide
Dofetilide__Herg channel blocker Eliglustat
Product Name
Dofetilide
Description
Herg channel blocker
Purity
>98%
CAS No.
115256-11-6
Molecular Formula
C19H27N3O5S2
Molecular Weight
441.56
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
White Solid
SMILES
CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
InChI
InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H
InChIKey
IXTMWRCNAAVVAI-UHFFFAOYSA-N
Safety Phrases
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S53 – Avoid exposure – obtain special instruction before use
S57 – Use appropriate containment to avoid environmental contamination
Risk Phrases:
R22 – Harmful if swallowed
R48 – Danger of serious damage to health by prolonged exposure
R51/53 – Toxic to aquatic organisms, may cause longterm adverse effects in the aquatic environment
R61 – May cause harm to the unborn child
R62 – Possible risk of impaired fertility
Hazard Phrases:
H302-H319-H360
Precautionary Phrases:
P201-P305 + P351 + P338-P308 + P313
Cite This Product
Dofetilide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-311)
References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19121406
Alternative Names
N-(4-{2-Methyl(2-{4-(methylsulfonyl)aminophenoxy}ethyl)aminoethyl}phenyl)methanesulfonamide, Tikosyn, UK 68798
Research Areas
Ion Channels, Neuroscience
PubChem ID
71329
Scientific Background
Dofetilide is a class III antiarrhythnic agent (1). It works by selectively blocking the rapid component of the delayed rectifier outward potassium current (2).
References
1. Lentz T.L., Hilleman D.E. (2000) Pharmacotherapy. 20(7): 776-786.
2. Roukoz H., Saliba W. (2007) Expert Rev Cardiovasc Ther. 5(1): 9-19.
Herg channel blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S53 – Avoid exposure – obtain special instruction before use
S57 – Use appropriate containment to avoid environmental contamination
Risk Phrases:
R22 – Harmful if swallowed
R48 – Danger of serious damage to health by prolonged exposure
R51/53 – Toxic to aquatic organisms, may cause longterm adverse effects in the aquatic environment
R61 – May cause harm to the unborn child
R62 – Possible risk of impaired fertility
Hazard Phrases:
H302-H319-H360
Precautionary Phrases:
P201-P305 + P351 + P338-P308 + P313
2. Roukoz H., Saliba W. (2007) Expert Rev Cardiovasc Ther. 5(1): 9-19.