Anti-Cytochrome P450 Reductase Antibody__Rabbit Anti-Rat Cytochrome P450 Reductase Polyclonal Bortezomib
Storage Buffer
PBS pH 7.4, 50% glycerol, 0.09% sodium azide
Storage Temperature
-20ºC
Shipping Temperature
Blue Ice or 4ºC
Purification
Protein A purified
Clonality
Polyclonal
Specificity
Detects ~77kDa.
Cite This Product
Rabbit Anti-Rat Cytochrome P450 Reductase Polyclonal (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPC-210)
Certificate of Analysis
1 µg/ml of SPC-210 was sufficient for detection of Cytochrome P450 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19120092
Alternative Names
Cytochrome C Reductase Antibody, CCR Antibody, CPR Antibody, P450R Antibody, CYPOR Antibody, DKFZp686G04235 Antibody, FLJ26468 Antibody, NADPH Cytochrome Antibody, P450 Reductase Antibody, NADPH dependent cytochrome P450 reductase Antibody, NADPH-cytochrome P450 reductase Antibody, P450 (cytochrome) oxidoreductase Antibody, P450 Cytochrome Oxidoreductase Antibody, P450R Antibody, POR Antibody
Research Areas
Cancer, Heat Shock, Cardiovascular System
Cellular Localization
Endoplasmic Reticulum, Endoplasmic reticulum membrane, Microsome
Accession Number
NP_113764.1
Gene ID
29441
Swiss Prot
P00388
Scientific Background
Cytochrome P450 Reductase is an enyme that is required for the transfer of electrons from NADPH to cytochrome P450 in microsomes. It has also been found to transfer electrons to Heme oxygenase and cytochrome B5. Cytochrome P450 Reductase is found localized to the endoplasmic reticulum membrane, tethered by its hydrophobic N-terminal tail. Mutations in the gene encoding Cytochrome P450 Reductase (POR) have been found to cause congenital adrenal hyperplasia, Antley-Bixler syndrome, amenorrhea and disordered steroidogenesis.
References
1. Pandey A.V. and Flück C.E. (2013). Pharmacology & therapeutics 138 (2): 229–54.
2. Jensen K. and Møller BL (2010). Phytochemistry 71 (2-3): 132–41.
3. Flück C.E. et al. (2004). Nature Genetics 36 (3): 228–230.
2. Jensen K. and Møller BL (2010). Phytochemistry 71 (2-3): 132–41.
3. Flück C.E. et al. (2004). Nature Genetics 36 (3): 228–230.