As is prolonged hospitalization [2, five, 72]. Since the danger aspects of wound infection are similar to variables responsible for disturbances in normal healing method, it appears affordable to treat each case of a chronic, difficult-healing wound as potentially infected. Based on the suggestions in the Centers for Illness Manage and Prevention, postoperative wounds in obstetrics and gynecology are classified as clean-contaminated [72]. Literature information estimate the incidence of infected woundsArch Gynecol Obstet (2015) 292:757in obstetrics and gynecology at 1 to 82 [1, 7, 1012]. With regard for the two most common procedures– abdominal hysterectomy and cesarean section, SSIs prices are 3.02.two and 1.81.three , respectively, while in ladies immediately after surgical treatment of cancer of your vulva, the percentage of wound infections is even greater and amounts to 219 [1, 7, 8, 103]. In most instances, microorganisms accountable for the infections of obstetric and gynecological postoperative wounds will be the patient’s endogenous bacterial flora. Most frequently isolated strains involve: Staphylococcus aureus, aerobic Gram-negative bacilli (Escherichia coli, Proteus sp., Klebsiella sp., Enterobacter sp.), Enterococcus sp., bhemolyzing streptococci of groups A, B, C and G, anaerobic bacterial species and Pseudomonas aeruginosa [1, 7, 10, 11]. Methicillin-resistant Staphylococcus aureus (MRSA) is detected in 23 inoculates from infected obstetric/gynecological wounds [7, 10, 11]. Fungi, DYRK4 Inhibitor Formulation mainly Candida sp. constitute a uncommon etiological issue in postoperative wound infections in gynecology [7]. Right management of infected wounds is often a multistage course of action involving wound debridement, lavasepsis and also the use of nearby and/or systemic agents (antiseptics, antibiotics). Within the era of increasing bacterial resistance to antibiotics, topical therapy with antiseptics plays an essential part, because the agents are significantly less selective but enable to achieve greater therapeutic concentrations within the wound, particularly in concomitant ischemic situations. Antiseptic dressings are an instance of such activity; among these, dressings containing silver will be the group of finest documented efficacy. Antiseptic properties of silver in the HDAC6 Inhibitor Gene ID remedy of wound infections had been currently recognized within the ancient instances. Today, silver dressings are a novel technique for topical remedy of infected and difficult-to-heal wounds. This is largely due to the silver’s broad spectrum of antimicrobial action against each fungi and bacteria including MRSA or vancomycinresistant enterococci (VRE) [20, 71, 737]. Combined with reasonably low toxicity, aforementioned properties make silver an incredibly precious tool for fighting pathogens responsible for infections of wounds immediately after iatrogenic activities. The mechanisms of silver action involve inhibition from the cellular respiration, binding of nucleic acids and causing their denaturation, inhibiting cell replication and altering the permeability of microbial cell membranes [20, 71, 73, 74, 78]. That is achieved by indicates of reactions of the silver ions with proteins, DNA or RNA and negatively charged chloride ions inside pathogens cells. An adverse side of this interaction may be the inactivation of very reactive and positively charged silver ions (Ag) by chlorides and many anionic complexes present in the wound bed. As a result, a fast drop inside the concentration of an active kind ofsilver that may successfully inhibit the development of microorganisms responsible for the i.