(arachidonic acid and linoleic acid), -3 PUFAs (EPA, DPA, DHA, and alpha-linolenic acid), their metabolites, plus the function of monounsaturated fatty acids in oxidative anxiety andEdited and reviewed by: Nada A. Abumrad, Washington University in St. Louis, Usa Correspondence: Chunjiong Wang [email protected] Jun Yang [email protected] Xu Zhang [email protected] Specialty section: This article was submitted to Lipid and Fatty Acid Investigation, a section in the journal Frontiers in Physiology Received: ten September 2021 Accepted: 01 November 2021 Published: 22 November 2021 Citation: Wang C, Yang J and Zhang X (2021) CD40 Activator list Editorial: The Part of Bioactive Lipids in Homeostasis and Pathology. Front. Physiol. 12:773632. doi: ten.3389/fphys.2021.Frontiers in Physiology | frontiersin.orgNovember 2021 | Volume 12 | ArticleWang et al.Editorial: The Part of Bioactive Lipids in Homeostasis and PathologyFIGURE 1 | Overview from the contributions incorporated below the Research Topic “Role of Bioactive Lipids in Homeostasis and pathology.” PUFA, polyunsaturated fatty acid; CyPGs, cyclopentenone prostaglandins; ARA, arachidonic acid; LA, linoleic acid; ALA, alpha-linolenic acid; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid; FA, fatty acid; HHcy, hyperhomocysteinemia; LPC, lysophosphatidylcholin; LPE, lysophosphatidylethanolamine; PI, phosphatidylinositol; Cer1P, ceramide-1-phosphate; Cer, ceramide; SMC, smooth muscle cell; DC, dendritic cell. See text for any brief description plus the reference of every single contributing article.inflammation were reviewed by Mazzocchi et al. Also, this critique report discussed the clinical studies carried out with different seed oils and marine animal-derived oils. This overview highlighted the truth that higher heterogeneity in oil composition plays a important function in wellness outcomes (Mazzocchi et al.). In addition, as reported by Liu et al., the metabolite profiles of arachidonic acid and DHA are altered in higher iodide-intakeinduced hypothyroid offspring rats. Iodide intake adjustment plus 1,25(OH)2D3 supplementation ameliorated hypothyroid and metabolic disturbances in conjunction with enhanced serum EET and hydroxyeicosatetraenoic acid (HETE) levels (Liu et al.). The effects of bioactive lipids in the respiratory system had been also emphasized within this Study Subject. A clinical study reported modifications in serum glycerophospholipids inside the acute exacerbation of chronic obstructive pulmonary illness (COPD) and various subtypes of COPD (Gai et al.). Sahanic et al. thoroughly reviewed bioactive lipid mediators in COVID-19 and influenza. They further promoted the present know-how relating to the mediator lipidome in severely affected COVID-19 individuals. They achieved this by investigating a publicly obtainable RNA-seq database of bronchoalveolar lavage cells (Sahanic et al.). The effects of sphingolipids around the cardiovascular program had been reported in a research post from Hua et al. Theauthors demonstrated that the myocardial Dopamine Receptor Modulator Source sphingolipid profile was altered following myocardial infarction injury. In specific, the ratio of ceramide-1-phosphate/ceramide was enhanced inside the myocardial infarction-injured heart tissue using a greater ceramide kinase expression (Hua et al.). The function and effects of metabolic enzymes of fatty acids are a vital subject in the field of bioactive lipids. Cytochrome P450 omega-hydroxylase 4a14 (Cyp4a14), a homolog of human CYP4A hydroxylase, catalyzes arachidonic acid to