De Barcelona, Barcelona, Spain. 10 Departament de Medicina, Universitat Aut oma de
De Barcelona, Barcelona, Spain. ten Departament de Medicina, Universitat Aut oma de Barcelona, Barcelona, Spain. 11Servei de Pneumologia, Akt1 Purity & Documentation Hospital de Bellvitge, Feixa Llarga s/n, 08907L Hospitalet de Llobregat, Spain. 12IDIBELL (Institut d’InvestigaciBiom ica de Bellvitge), Gran By way of de L’Hospitalet 199, 08908 Hospitalet de Llobregat, Spain. 13Arizona Respiratory Center, Tucson, AZ, USA. 14Servei de Pneumologia, Hospital Universitari Son Espases, Carretera de Valldemosa 79, 07010 Palma de Mallorca, Spain. 15Institut de InvestigaciSanit ia de Palma (IdISPa), Carretera de Valldemossa 79, Palma, Spain. 16Thorax Institute, Hospital Cl ic, Barcelona, Spain. 17Institut d’InvestigaciBiom ica AgustPi I Sunyer (IDIBAPS), Barcelona, Spain. 18Universitat de Barcelona, Barcelona, Spain. 19FundaciInvestigaciSanit ia Illes Balears (FISIB), Palma de Mallorca, Spain. Received: four January 2015 Accepted: eight January 2015 Published: 17 January 2015 References 1. Lopez AD, Shibuya K, Rao C, Mathers CD, Hansell AL, Held LS, et al. Chronic obstructive pulmonary disease: current burden and future projections. Eur Respir J. 2006;27:39712. 2. Murray CJ, L ez AD. Measuring the Global Burden of Disease. N Engl J Med. 2013;369:4487. three. Coultas DB, Mapel D, Gagnon R, Lydick E. The health influence of undiagnosed airflow obstruction in a national sample of United states of america adults. Am J Respir Crit Care Med. 2001;164:372. four. Rennard S, Decramer M, Calverley PM, Pride NB, COX-3 Purity & Documentation Soriano JB, Vermeire PA, et al. Impact of COPD in North America and Europe in 2000: subjects’ viewpoint of Confronting COPD International Survey. Eur Respir J. 2002;20:79905. five. Soriano JB, Ancochea J, Miravitlles M, Garc -R F, Duran-Tauleria E, Mu z L, et al. Current trends in COPD prevalence in Spain: a repeated cross-sectional survey 1997007. Eur Respir J. 2010;36:7585. six. Soriano JB, Miravitlles M, Border s L, Duran-Tauleria E, Garc R F, Mart ez J, et al. Geographical variations inside the prevalence of COPD in Spain: Relationship to Smoking, Death Prices and also other Figuring out Things. Arch Bronconeumol. 2010;46:5220. 7. Bednarek M, Maciejewski J, Wozniak M, Kuca P, Zielinski J. Prevalence, severity and underdiagnosis of COPD within the main care setting. Thorax. 2008;63:402. eight. Jordan RE, Lam KB, Cheng KK, Miller MR, Marsh JL, Ayres JG, et al. Case getting for chronic obstructive pulmonary disease: a model for optimising a targered strategy. Thorax. 2010;65:492. 9. Miravitlles M, Soriano JB, Garc -R F, Mu z L, Duran-Tauleria E, Sanchez G, et al. Prevalence of COPD in Spain: effect of undiagnosed COPD on quality of life and each day life activities. Thorax. 2009;64:863. ten. Soriano JB, Zielinski J, Value D. Screening for and early detection of chronic obstructive pulmonary illness. Lancet. 2009;374:7212. 11. Zoia MC, Corsico AG, Beccaria M, Guarnone R, Cervio G, Testi R, et al. Exacerbations as a beginning point of pro-active chronic obstructive pulmonary illness management. Respir Med. 2005;99:15685. 12. Bastin AJ, Starling L, Ahmed R, Dinham A, Hill N, Stern M, et al. High prevalence of undiagnosed and serious chronic obstructive pulmonary disease at first hospital admission with acute exacerbation. Chron Respir Dis. 2010;7:91. 13. Garcia-Aymerich J, G ez FP, AntJM. Phenotypic characterization and course of chronic obstructive pulmonary disease (COPD) in the PAC-COPD Study: style and procedures. Arch Bronconeumol. 2009;45:41. 14. BarberJA, Peces-Barba G, AgustAG, Izquierdo JL, MonsE, Montemayor T, et al. Clinical.