Product Name :
Leriglitazone hydrochloride
Description:
Leriglitazone (Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) hydrochloride PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) hydrochloride binds to the PPARγ C-terminal ligand-binding domain (LBD) with a Ki of 1.2 μM，Leriglitazone induces transcriptional efficacy of the PPARγ (LBD) with an EC50 of 680 nM[1].
CAS:
146062-46-6
Molecular Weight:
408.90
Formula:
C19H21ClN2O4S
Chemical Name:
Smiles :
Cl.CC(O)C1=CC=C(CCOC2C=CC(CC3SC(=O)NC3=O)=CC=2)N=C1
InChiKey:
SBHOQYCDAHAMDW-UHFFFAOYSA-N
InChi :
InChI=1S/C19H20N2O4S.ClH/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17;/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24);1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Leriglitazone (Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone.{{Terutroban} web|{Terutroban} GPCR/G Protein|{Terutroban} Purity & Documentation|{Terutroban} References|{Terutroban} custom synthesis|{Terutroban} Autophagy} Leriglitazone (Hydroxypioglitazone) hydrochloride PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) hydrochloride binds to the PPARγ C-terminal ligand-binding domain (LBD) with a Ki of 1.2 μM，Leriglitazone induces transcriptional efficacy of the PPARγ (LBD) with an EC50 of 680 nM[1].|Product information|CAS Number: 146062-46-6|Molecular Weight: 408.90|Formula: C19H21ClN2O4S|Smiles: Cl.CC(O)C1=CC=C(CCOC2C=CC(CC3SC(=O)NC3=O)=CC=2)N=C1|InChiKey: SBHOQYCDAHAMDW-UHFFFAOYSA-N|InChi: InChI=1S/C19H20N2O4S.ClH/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17;/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{ERK1/2 inhibitor 2} site|{ERK1/2 inhibitor 2} Apoptosis|{ERK1/2 inhibitor 2} Protocol|{ERK1/2 inhibitor 2} Formula|{ERK1/2 inhibitor 2} custom synthesis|{ERK1/2 inhibitor 2} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:28440459 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Mosure SA,et al. Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone. J Med Chem. 2019 Feb 28;62(4):2008-2023.Products are for research use only. Not for human use.|