Product Name :
Naftopidil hydrochloride
Description:
Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia.
CAS:
1164469-60-6
Molecular Weight:
428.95
Formula:
C24H29ClN2O3
Chemical Name:
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride
Smiles :
Cl.COC1=CC=CC=C1N1CCN(CC(O)COC2=CC=CC3=CC=CC=C32)CC1
InChiKey:
VQAAEWMEVIOHTJ-UHFFFAOYSA-N
InChi :
InChI=1S/C24H28N2O3.ClH/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;/h2-12,20,27H,13-18H2,1H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ampicillin} MedChemExpress|{Ampicillin} Anti-infection|{Ampicillin} Purity & Documentation|{Ampicillin} Data Sheet|{Ampicillin} manufacturer|{Ampicillin} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively.{{Stenoparib} web|{Stenoparib} Inhibitor|{Stenoparib} Epigenetics|{Stenoparib} Protocol|{Stenoparib} In stock|{Stenoparib} custom synthesis} Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia.PMID:23819239 |Product information|CAS Number: 1164469-60-6|Molecular Weight: 428.95|Formula: C24H29ClN2O3|Chemical Name: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride|Smiles: Cl.COC1=CC=CC=C1N1CCN(CC(O)COC2=CC=CC3=CC=CC=C32)CC1|InChiKey: VQAAEWMEVIOHTJ-UHFFFAOYSA-N|InChi: InChI=1S/C24H28N2O3.ClH/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;/h2-12,20,27H,13-18H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC. Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.|In Vivo:|Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model.|Products are for research use only. Not for human use.|