Product Name :
GNE-6468
Description:
GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC.
CAS:
1677668-27-7
Molecular Weight:
433.84
Formula:
C23H16ClN3O4
Chemical Name:
4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acid
Smiles :
OC(=O)C1=CC=C(C=C1O)C1N=C(C(=O)C2C(Cl)=CC=CC=2C2CC2)N2C=CC=NC2=1
InChiKey:
GIYKJPISDNWSJD-UHFFFAOYSA-N
InChi :
InChI=1S/C23H16ClN3O4/c24-16-4-1-3-14(12-5-6-12)18(16)20(29)22-26-19(21-25-9-2-10-27(21)22)13-7-8-15(23(30)31)17(28)11-13/h1-4,7-12,28H,5-6H2,(H,30,31)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC.|Product information|CAS Number: 1677668-27-7|Molecular Weight: 433.84|Formula: C23H16ClN3O4|Chemical Name: 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acid|Smiles: OC(=O)C1=CC=C(C=C1O)C1N=C(C(=O)C2C(Cl)=CC=CC=2C2CC2)N2C=CC=NC2=1|InChiKey: GIYKJPISDNWSJD-UHFFFAOYSA-N|InChi: InChI=1S/C23H16ClN3O4/c24-16-4-1-3-14(12-5-6-12)18(16)20(29)22-26-19(21-25-9-2-10-27(21)22)13-7-8-15(23(30)31)17(28)11-13/h1-4,7-12,28H,5-6H2,(H,30,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5 mg/mL (11.{{MARK-IN-2} web|{MARK-IN-2} AMPK|{MARK-IN-2} Activator|{MARK-IN-2} Protocol|{MARK-IN-2} Formula|{MARK-IN-2} manufacturer} 52 mM; Need ultrasonic).{{Vitamin D2} web|{Vitamin D2} Metabolic Enzyme/Protease|{Vitamin D2} Biological Activity|{Vitamin D2} Data Sheet|{Vitamin D2} manufacturer|{Vitamin D2} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:25040798 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|GNE-6468 (compound 28) displays high predicted clearance values in human and rodent hepatocytes (CLhep = 17 and 42 mL/min/kg, respectively) .|Products are for research use only. Not for human use.|